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Page 1
Chlorin e6-mediated photodynamic effect diminishes therapeutic potential of 5-aza-2'-deoxycytidine-based whole-tumour-cell vaccine in mice bearing squamous cell carcinoma SCCVII.
Marczynska J, Banas M, Guzik K, Koltun M, Majewski P, Cichy J, Krzykawska-Serda M, Makarska A, Kwitniewski M. Marczynska J, et al. Among authors: koltun m. J Photochem Photobiol B. 2015 Dec;153:455-62. doi: 10.1016/j.jphotobiol.2015.10.025. Epub 2015 Oct 28. J Photochem Photobiol B. 2015. PMID: 26569454
Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold.
Schwartz BD, Skinner-Adams TS, Andrews KT, Coster MJ, Edstein MD, MacKenzie D, Charman SA, Koltun M, Blundell S, Campbell A, Pouwer RH, Quinn RJ, Beattie KD, Healy PC, Davis RA. Schwartz BD, et al. Among authors: koltun m. Org Biomol Chem. 2015 Feb 7;13(5):1558-70. doi: 10.1039/c4ob01849d. Org Biomol Chem. 2015. PMID: 25490858 Free article.
Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease.
Bahia MT, Nascimento AF, Mazzeti AL, Marques LF, Gonçalves KR, Mota LW, Diniz Lde F, Caldas IS, Talvani A, Shackleford DM, Koltun M, Saunders J, White KL, Scandale I, Charman SA, Chatelain E. Bahia MT, et al. Among authors: koltun m. Antimicrob Agents Chemother. 2014 Aug;58(8):4362-70. doi: 10.1128/AAC.02754-13. Epub 2014 May 19. Antimicrob Agents Chemother. 2014. PMID: 24841257 Free PMC article.
Two analogues of fenarimol show curative activity in an experimental model of Chagas disease.
Keenan M, Chaplin JH, Alexander PW, Abbott MJ, Best WM, Khong A, Botero A, Perez C, Cornwall S, Thompson RA, White KL, Shackleford DM, Koltun M, Chiu FC, Morizzi J, Ryan E, Campbell M, von Geldern TW, Scandale I, Chatelain E, Charman SA. Keenan M, et al. Among authors: koltun m. J Med Chem. 2013 Dec 27;56(24):10158-70. doi: 10.1021/jm401610c. Epub 2013 Dec 4. J Med Chem. 2013. PMID: 24304150 Free PMC article.
Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.
Coteron JM, Marco M, Esquivias J, Deng X, White KL, White J, Koltun M, El Mazouni F, Kokkonda S, Katneni K, Bhamidipati R, Shackleford DM, Angulo-Barturen I, Ferrer SB, Jiménez-Díaz MB, Gamo FJ, Goldsmith EJ, Charman WN, Bathurst I, Floyd D, Matthews D, Burrows JN, Rathod PK, Charman SA, Phillips MA. Coteron JM, et al. Among authors: koltun m. J Med Chem. 2011 Aug 11;54(15):5540-61. doi: 10.1021/jm200592f. Epub 2011 Jul 14. J Med Chem. 2011. PMID: 21696174 Free PMC article.
The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).
Dong Y, Wittlin S, Sriraghavan K, Chollet J, Charman SA, Charman WN, Scheurer C, Urwyler H, Santo Tomas J, Snyder C, Creek DJ, Morizzi J, Koltun M, Matile H, Wang X, Padmanilayam M, Tang Y, Dorn A, Brun R, Vennerstrom JL. Dong Y, et al. Among authors: koltun m. J Med Chem. 2010 Jan 14;53(1):481-91. doi: 10.1021/jm901473s. J Med Chem. 2010. PMID: 19924861
Mechanism of hypoalbuminemia in rodents.
Koltun M, Nikolovski J, Strong K, Nikolic-Paterson D, Comper WD. Koltun M, et al. Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1604-10. doi: 10.1152/ajpheart.00808.2004. Epub 2004 Nov 11. Am J Physiol Heart Circ Physiol. 2005. PMID: 15539420 Free article.
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