Zheng N - Search Results

1

A highly sensitive and selective LC-MS/MS method to quantify asunaprevir, an HCV NS3 protease inhibitor, in human plasma in support of pharmacokinetic studies.

Kandoussi H, Jiang H, Zeng J, Zheng N, Kadiyala P, Eley T, He B, Garimella T, Demers R, Cojocaru L, Aubry AF, Arnold ME. Kandoussi H, et al. Among authors: zheng n. J Pharm Biomed Anal. 2016 Feb 5;119:145-51. doi: 10.1016/j.jpba.2015.11.028. Epub 2015 Nov 23. J Pharm Biomed Anal. 2016. PMID: 26683987

2

Utility of porous graphitic carbon stationary phase in quantitative liquid chromatography/tandem mass spectrometry bioanalysis: quantitation of diastereomers in plasma.

Xia YQ, Jemal M, Zheng N, Shen X. Xia YQ, et al. Among authors: zheng n. Rapid Commun Mass Spectrom. 2006;20(12):1831-7. doi: 10.1002/rcm.2517. Rapid Commun Mass Spectrom. 2006. PMID: 16705646

3

Simultaneous determination of a selective adenosine 2A agonist, BMS-068645, and its acid metabolite in human plasma by liquid chromatography-tandem mass spectrometry--evaluation of the esterase inhibitor, diisopropyl fluorophosphate, in the stabilization of a labile ester-containing drug.

Zeng J, Onthank D, Crane P, Unger S, Zheng N, Pasas-Farmer S, Arnold M. Zeng J, et al. Among authors: zheng n. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):77-84. doi: 10.1016/j.jchromb.2006.12.054. Epub 2007 Jan 13. J Chromatogr B Analyt Technol Biomed Life Sci. 2007. PMID: 17280881

4

Effective screening approach to select esterase inhibitors used for stabilizing ester-containing prodrugs analyzed by LC-MS/MS.

Fung EN, Zheng N, Arnold ME, Zeng J. Fung EN, et al. Among authors: zheng n. Bioanalysis. 2010 Apr;2(4):733-43. doi: 10.4155/bio.10.30. Bioanalysis. 2010. PMID: 21083271

5

A convenient strategy for quantitative determination of drug concentrations in tissue homogenates using a liquid chromatography/tandem mass spectrometry assay for plasma samples.

Jiang H, Zeng J, Zheng N, Kandoussi H, Peng Q, Valentine JL, Lange RW, Arnold ME. Jiang H, et al. Among authors: zheng n. Anal Chem. 2011 Aug 15;83(16):6237-44. doi: 10.1021/ac200820q. Epub 2011 Jul 21. Anal Chem. 2011. PMID: 21692511

6

A user-friendly robotic sample preparation program for fully automated biological sample pipetting and dilution to benefit the regulated bioanalysis.

Jiang H, Ouyang Z, Zeng J, Yuan L, Zheng N, Jemal M, Arnold ME. Jiang H, et al. Among authors: zheng n. J Lab Autom. 2012 Jun;17(3):211-21. doi: 10.1177/2211068211429775. Epub 2012 Jan 24. J Lab Autom. 2012. PMID: 22357562

7

Esterase inhibitors as ester-containing drug stabilizers and their hydrolytic products: potential contributors to the matrix effects on bioanalysis by liquid chromatography/tandem mass spectrometry.

Zheng N, Fung EN, Buzescu A, Arnold ME, Zeng J. Zheng N, et al. Rapid Commun Mass Spectrom. 2012 Jun 15;26(11):1291-304. doi: 10.1002/rcm.6230. Rapid Commun Mass Spectrom. 2012. PMID: 22555922

8

A simplified and completely automated workflow for regulated LC-MS/MS bioanalysis using cap-piercing direct sampling and evaporation-free solid phase extraction.

Zheng N, Buzescu A, Pasas-Farmer S, Arnold ME, Ouyang Z, Jemal M, Peng Q, Van Vleet T, Zeng J. Zheng N, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Mar 15;921-922:64-74. doi: 10.1016/j.jchromb.2013.01.028. Epub 2013 Feb 4. J Chromatogr B Analyt Technol Biomed Life Sci. 2013. PMID: 23435343

9

A rapid, accurate and robust UHPLC-MS/MS method for quantitative determination of BMS-927711, a CGRP receptor antagonist, in plasma in support of non-clinical toxicokinetic studies.

Zheng N, Zeng J, Akinsanya B, Buzescu A, Xia YQ, Ly V, Trouba K, Peng Q, Aubry AF, Arnold ME. Zheng N, et al. J Pharm Biomed Anal. 2013 Sep;83:237-48. doi: 10.1016/j.jpba.2013.05.019. Epub 2013 May 20. J Pharm Biomed Anal. 2013. PMID: 23770636

10

Improved liquid-liquid extraction with inter-well volume replacement dilution workflow and its application to quantify BMS-927711 in rat dried blood spots by UHPLC-MS/MS.

Zheng N, Zeng J, Ji QC, Angeles A, Buzescu A, Basdeo S, Aubry AF, Trouba K, Patrone LM, Peng Q, Arnold ME. Zheng N, et al. J Pharm Biomed Anal. 2014 Feb;89:240-50. doi: 10.1016/j.jpba.2013.11.017. Epub 2013 Nov 19. J Pharm Biomed Anal. 2014. PMID: 24316424

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