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Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Bjørge MD, Hildrestrand GA, Scheffler K, Suganthan R, Rolseth V, Kuśnierczyk A, Rowe AD, Vågbø CB, Vetlesen S, Eide L, Slupphaug G, Nakabeppu Y, Bredy TW, Klungland A, Bjørås M. Bjørge MD, et al. Among authors: bredy tw. Cell Rep. 2015 Dec 29;13(12):2671-8. doi: 10.1016/j.celrep.2015.12.001. Epub 2015 Dec 17. Cell Rep. 2015. PMID: 26711335 Free article.
The DNA modification N6-methyl-2'-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction.
Li X, Zhao Q, Wei W, Lin Q, Magnan C, Emami MR, Wearick-Silva LE, Viola TW, Marshall PR, Yin J, Madugalle SU, Wang Z, Nainar S, Vågbø CB, Leighton LJ, Zajaczkowski EL, Ke K, Grassi-Oliveira R, Bjørås M, Baldi PF, Spitale RC, Bredy TW. Li X, et al. Among authors: bredy tw. Nat Neurosci. 2019 Apr;22(4):534-544. doi: 10.1038/s41593-019-0339-x. Epub 2019 Feb 18. Nat Neurosci. 2019. PMID: 30778148 Free PMC article.
ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3.
Wei W, Zhao Q, Wang Z, Liau WS, Basic D, Ren H, Marshall PR, Zajaczkowski EL, Leighton LJ, Madugalle SU, Musgrove M, Periyakaruppiah A, Shi J, Zhang J, Mattick JS, Mercer TR, Spitale RC, Li X, Bredy TW. Wei W, et al. Among authors: bredy tw. Cell Rep. 2022 Mar 22;38(12):110546. doi: 10.1016/j.celrep.2022.110546. Cell Rep. 2022. PMID: 35320727 Free PMC article.
Disrupting the hippocampal Piwi pathway enhances contextual fear memory in mice.
Leighton LJ, Wei W, Marshall PR, Ratnu VS, Li X, Zajaczkowski EL, Spadaro PA, Khandelwal N, Kumar A, Bredy TW. Leighton LJ, et al. Among authors: bredy tw. Neurobiol Learn Mem. 2019 May;161:202-209. doi: 10.1016/j.nlm.2019.04.002. Epub 2019 Apr 6. Neurobiol Learn Mem. 2019. PMID: 30965112
78 results