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Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway.
Rajagopal S, Kumar DP, Mahavadi S, Bhattacharya S, Zhou R, Corvera CU, Bunnett NW, Grider JR, Murthy KS. Rajagopal S, et al. Among authors: kumar dp. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 1;304(5):G527-35. doi: 10.1152/ajpgi.00388.2012. Epub 2012 Dec 28. Am J Physiol Gastrointest Liver Physiol. 2013. PMID: 23275618 Free PMC article.
Bile acids: emerging role in management of liver diseases.
Asgharpour A, Kumar D, Sanyal A. Asgharpour A, et al. Hepatol Int. 2015 Oct;9(4):527-33. doi: 10.1007/s12072-015-9656-7. Epub 2015 Aug 29. Hepatol Int. 2015. PMID: 26320013 Free PMC article. Review.
Jun kinase-induced overexpression of leukemia-associated Rho GEF (LARG) mediates sustained hypercontraction of longitudinal smooth muscle in inflammation.
Al-Shboul O, Nalli AD, Kumar DP, Zhou R, Mahavadi S, Kuemmerle JF, Grider JR, Murthy KS. Al-Shboul O, et al. Among authors: kumar dp. Am J Physiol Cell Physiol. 2014 Jun 15;306(12):C1129-41. doi: 10.1152/ajpcell.00021.2014. Epub 2014 Apr 16. Am J Physiol Cell Physiol. 2014. PMID: 24740538 Free PMC article.
Hypercontractility of intestinal longitudinal smooth muscle induced by cytokines is mediated by the nuclear factor-κB/AMP-activated kinase/myosin light chain kinase pathway.
Nalli AD, Kumar DP, Mahavadi S, Al-Shboul O, Alkahtani R, Kuemmerle JF, Grider JR, Murthy KS. Nalli AD, et al. Among authors: kumar dp. J Pharmacol Exp Ther. 2014 Jul;350(1):89-98. doi: 10.1124/jpet.113.212522. Epub 2014 Apr 25. J Pharmacol Exp Ther. 2014. PMID: 24769544 Free PMC article.
Regulation of Gβγi-dependent PLC-β3 activity in smooth muscle: inhibitory phosphorylation of PLC-β3 by PKA and PKG and stimulatory phosphorylation of Gαi-GTPase-activating protein RGS2 by PKG.
Nalli AD, Kumar DP, Al-Shboul O, Mahavadi S, Kuemmerle JF, Grider JR, Murthy KS. Nalli AD, et al. Among authors: kumar dp. Cell Biochem Biophys. 2014 Nov;70(2):867-80. doi: 10.1007/s12013-014-9992-6. Cell Biochem Biophys. 2014. PMID: 24777815 Free PMC article.
The multifaceted role of natriuretic peptides in metabolic syndrome.
Santhekadur PK, Kumar DP, Seneshaw M, Mirshahi F, Sanyal AJ. Santhekadur PK, et al. Among authors: kumar dp. Biomed Pharmacother. 2017 Aug;92:826-835. doi: 10.1016/j.biopha.2017.05.136. Epub 2017 Jun 7. Biomed Pharmacother. 2017. PMID: 28599248 Free PMC article. Review.
86 results