Cai S - Search Results

1

Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth.

Chen L, Zeng X, Kleibeuker E, Buffa F, Barberis A, Leek RD, Roxanis I, Zhang W, Worth A, Beech JS, Harris AL, Cai S. Chen L, et al. Among authors: cai s. Oncotarget. 2016 Feb 23;7(8):9353-67. doi: 10.18632/oncotarget.6981. Oncotarget. 2016. PMID: 26814432 Free PMC article.

2

Roles of tetrahydrobiopterin in promoting tumor angiogenesis.

Chen L, Zeng X, Wang J, Briggs SS, O'Neill E, Li J, Leek R, Kerr DJ, Harris AL, Cai S. Chen L, et al. Among authors: cai s. Am J Pathol. 2010 Nov;177(5):2671-80. doi: 10.2353/ajpath.2010.100025. Epub 2010 Sep 16. Am J Pathol. 2010. PMID: 20847284 Free PMC article.

3

Copper chelator ATN-224 inhibits endothelial function by multiple mechanisms.

Lowndes SA, Sheldon HV, Cai S, Taylor JM, Harris AL. Lowndes SA, et al. Among authors: cai s. Microvasc Res. 2009 May;77(3):314-26. doi: 10.1016/j.mvr.2009.01.003. Epub 2009 Jan 27. Microvasc Res. 2009. PMID: 19323979

4

GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.

Cai S, Alp NJ, McDonald D, Smith I, Kay J, Canevari L, Heales S, Channon KM. Cai S, et al. Cardiovasc Res. 2002 Sep;55(4):838-49. doi: 10.1016/s0008-6363(02)00460-1. Cardiovasc Res. 2002. PMID: 12176133

5

Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.

Crabtree MJ, Tatham AL, Al-Wakeel Y, Warrick N, Hale AB, Cai S, Channon KM, Alp NJ. Crabtree MJ, et al. Among authors: cai s. J Biol Chem. 2009 Jan 9;284(2):1136-44. doi: 10.1074/jbc.M805403200. Epub 2008 Nov 14. J Biol Chem. 2009. PMID: 19011239 Free article.

6

GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.

Tatham AL, Crabtree MJ, Warrick N, Cai S, Alp NJ, Channon KM. Tatham AL, et al. Among authors: cai s. J Biol Chem. 2009 May 15;284(20):13660-13668. doi: 10.1074/jbc.M807959200. Epub 2009 Mar 13. J Biol Chem. 2009. PMID: 19286659 Free PMC article.

7

Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.

Bendall JK, Alp NJ, Warrick N, Cai S, Adlam D, Rockett K, Yokoyama M, Kawashima S, Channon KM. Bendall JK, et al. Among authors: cai s. Circ Res. 2005 Oct 28;97(9):864-71. doi: 10.1161/01.RES.0000187447.03525.72. Epub 2005 Sep 22. Circ Res. 2005. PMID: 16179591

8

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.

Alp NJ, Mussa S, Khoo J, Cai S, Guzik T, Jefferson A, Goh N, Rockett KA, Channon KM. Alp NJ, et al. Among authors: cai s. J Clin Invest. 2003 Sep;112(5):725-35. doi: 10.1172/JCI17786. J Clin Invest. 2003. PMID: 12952921 Free PMC article.

9

Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.

Cai S, Khoo J, Channon KM. Cai S, et al. Cardiovasc Res. 2005 Mar 1;65(4):823-31. doi: 10.1016/j.cardiores.2004.10.040. Cardiovasc Res. 2005. PMID: 15721862

10

GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats.

Meininger CJ, Cai S, Parker JL, Channon KM, Kelly KA, Becker EJ, Wood MK, Wade LA, Wu G. Meininger CJ, et al. Among authors: cai s. FASEB J. 2004 Dec;18(15):1900-2. doi: 10.1096/fj.04-1702fje. Epub 2004 Oct 5. FASEB J. 2004. PMID: 15467010

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