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Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.
Palles C, Cazier JB, Howarth KM, Domingo E, Jones AM, Broderick P, Kemp Z, Spain SL, Guarino E, Salguero I, Sherborne A, Chubb D, Carvajal-Carmona LG, Ma Y, Kaur K, Dobbins S, Barclay E, Gorman M, Martin L, Kovac MB, Humphray S; CORGI Consortium; WGS500 Consortium; Lucassen A, Holmes CC, Bentley D, Donnelly P, Taylor J, Petridis C, Roylance R, Sawyer EJ, Kerr DJ, Clark S, Grimes J, Kearsey SE, Thomas HJ, McVean G, Houlston RS, Tomlinson I. Palles C, et al. Among authors: kearsey se. Nat Genet. 2013 Feb;45(2):136-44. doi: 10.1038/ng.2503. Epub 2012 Dec 23. Nat Genet. 2013. PMID: 23263490 Free PMC article.
Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.
Soriano I, Vazquez E, De Leon N, Bertrand S, Heitzer E, Toumazou S, Bo Z, Palles C, Pai CC, Humphrey TC, Tomlinson I, Cotterill S, Kearsey SE. Soriano I, et al. Among authors: kearsey se. PLoS Genet. 2021 Jul 6;17(7):e1009526. doi: 10.1371/journal.pgen.1009526. eCollection 2021 Jul. PLoS Genet. 2021. PMID: 34228709 Free PMC article.
Surveying genome replication.
Kearsey S. Kearsey S. Genome Biol. 2002;3(6):REVIEWS1016. doi: 10.1186/gb-2002-3-6-reviews1016. Epub 2002 May 24. Genome Biol. 2002. PMID: 12093380 Free PMC article. Review.
Initiation of DNA replication in yeast chromosomes.
Kearsey SE. Kearsey SE. Philos Trans R Soc Lond B Biol Sci. 1987 Dec 15;317(1187):517-23. doi: 10.1098/rstb.1987.0078. Philos Trans R Soc Lond B Biol Sci. 1987. PMID: 2894686
Essential role of MCM proteins in premeiotic DNA replication.
Lindner K, Gregán J, Montgomery S, Kearsey SE. Lindner K, et al. Among authors: kearsey se. Mol Biol Cell. 2002 Feb;13(2):435-44. doi: 10.1091/mbc.01-11-0537. Mol Biol Cell. 2002. PMID: 11854402 Free PMC article.
73 results