Chiu TL - Search Results

1

Methemoglobin Formation and Characterization of Hemoglobin Adducts of Carcinogenic Aromatic Amines and Heterocyclic Aromatic Amines.

Pathak KV, Chiu TL, Amin EA, Turesky RJ. Pathak KV, et al. Among authors: chiu tl. Chem Res Toxicol. 2016 Mar 21;29(3):255-69. doi: 10.1021/acs.chemrestox.5b00418. Epub 2016 Feb 22. Chem Res Toxicol. 2016. PMID: 26824300 Free PMC article.

2

Development of a comprehensive, validated pharmacophore hypothesis for anthrax toxin lethal factor (LF) inhibitors using genetic algorithms, Pareto scoring, and structural biology.

Chiu TL, Amin EA. Chiu TL, et al. J Chem Inf Model. 2012 Jul 23;52(7):1886-97. doi: 10.1021/ci300121p. Epub 2012 Jun 25. J Chem Inf Model. 2012. PMID: 22697455 Free PMC article.

3

Identification of novel anthrax toxin countermeasures using in silico methods.

Chiu TL, Maize KM, Amin EA. Chiu TL, et al. Methods Mol Biol. 2013;993:177-84. doi: 10.1007/978-1-62703-342-8_12. Methods Mol Biol. 2013. PMID: 23568471 Free PMC article.

4

Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.

Kurbanov EK, Chiu TL, Solberg J, Francis S, Maize KM, Fernandez J, Johnson RL, Hawkinson JE, Walters MA, Finzel BC, Amin EA. Kurbanov EK, et al. Among authors: chiu tl. J Med Chem. 2015 Nov 12;58(21):8723-33. doi: 10.1021/acs.jmedchem.5b01446. Epub 2015 Oct 29. J Med Chem. 2015. PMID: 26492514

5

Identification of novel non-hydroxamate anthrax toxin lethal factor inhibitors by topomeric searching, docking and scoring, and in vitro screening.

Chiu TL, Solberg J, Patil S, Geders TW, Zhang X, Rangarajan S, Francis R, Finzel BC, Walters MA, Hook DJ, Amin EA. Chiu TL, et al. J Chem Inf Model. 2009 Dec;49(12):2726-34. doi: 10.1021/ci900186w. J Chem Inf Model. 2009. PMID: 19928768 Free PMC article.

6

Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP.

Jia Y, Chiu TL, Amin EA, Polunovsky V, Bitterman PB, Wagner CR. Jia Y, et al. Among authors: chiu tl. Eur J Med Chem. 2010 Apr;45(4):1304-13. doi: 10.1016/j.ejmech.2009.11.054. Epub 2009 Dec 6. Eur J Med Chem. 2010. PMID: 20060622 Free PMC article.

7

Total synthesis and evaluation of C26-hydroxyepothilone D derivatives for photoaffinity labeling of beta-tubulin.

Reiff EA, Nair SK, Henri JT, Greiner JF, Reddy BS, Chakrasali R, David SA, Chiu TL, Amin EA, Himes RH, Vander Velde DG, Georg GI. Reiff EA, et al. Among authors: chiu tl. J Org Chem. 2010 Jan 1;75(1):86-94. doi: 10.1021/jo901752v. J Org Chem. 2010. PMID: 19954175 Free PMC article.

8

Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells.

Hutt OE, Reddy BS, Nair SK, Reiff EA, Henri JT, Greiner JF, Chiu TL, Vandervelde DG, Amin EA, Himes RH, Georg GI. Hutt OE, et al. Among authors: chiu tl. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4904-6. doi: 10.1016/j.bmcl.2008.07.024. Epub 2008 Jul 11. Bioorg Med Chem Lett. 2008. PMID: 18684624 Free PMC article.

9

Total synthesis and evaluation of 22-(3-azidobenzoyloxy)methyl epothilone C for photoaffinity labeling of beta-tubulin.

Hutt OE, Inagaki J, Reddy BS, Nair SK, Reiff EA, Henri JT, Greiner JF, VanderVelde DG, Chiu TL, Amin EA, Himes RH, Georg GI. Hutt OE, et al. Among authors: chiu tl. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3293-6. doi: 10.1016/j.bmcl.2009.04.077. Epub 2009 Apr 22. Bioorg Med Chem Lett. 2009. PMID: 19428248 Free PMC article.

10

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.

Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, Bae YK, Wulfkuhle JD, Gallagher RI, Petricoin EF Rd, Norris B, Flory CM, Schumacher RJ, O'Sullivan MG, Cao Q, Chu H, Lipscomb JD, Atkins WM, Gupta K, Kelekar A, Blair IA, Capdevila JH, Falck JR, Sligar SG, Poulos TL, Georg GI, Ambrose E, Potter DA. Guo Z, et al. Among authors: chiu tl. Cell Chem Biol. 2017 Oct 19;24(10):1259-1275.e6. doi: 10.1016/j.chembiol.2017.08.009. Epub 2017 Sep 14. Cell Chem Biol. 2017. PMID: 28919040 Free PMC article.

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