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Filaggrin genotype does not determine the skin's threshold to UV-induced erythema.
Forbes D, Johnston L, Gardner J, MacCallum SF, Campbell LE, Dinkova-Kostova AT, McLean WHI, Ibbotson SH, Dawe RS, Brown SJ. Forbes D, et al. Among authors: mclean whi. J Allergy Clin Immunol. 2016 Apr;137(4):1280-1282.e3. doi: 10.1016/j.jaci.2015.11.022. Epub 2016 Jan 29. J Allergy Clin Immunol. 2016. PMID: 26830116 Free PMC article. No abstract available.
Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy.
Brown SJ, Asai Y, Cordell HJ, Campbell LE, Zhao Y, Liao H, Northstone K, Henderson J, Alizadehfar R, Ben-Shoshan M, Morgan K, Roberts G, Masthoff LJ, Pasmans SG, van den Akker PC, Wijmenga C, Hourihane JO, Palmer CN, Lack G, Clarke A, Hull PR, Irvine AD, McLean WH. Brown SJ, et al. J Allergy Clin Immunol. 2011 Mar;127(3):661-7. doi: 10.1016/j.jaci.2011.01.031. J Allergy Clin Immunol. 2011. PMID: 21377035 Free PMC article.
One remarkable molecule: filaggrin.
Brown SJ, McLean WH. Brown SJ, et al. J Invest Dermatol. 2012 Mar;132(3 Pt 2):751-62. doi: 10.1038/jid.2011.393. Epub 2011 Dec 8. J Invest Dermatol. 2012. PMID: 22158554 Free PMC article. Review.
South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin.
Thawer-Esmail F, Jakasa I, Todd G, Wen Y, Brown SJ, Kroboth K, Campbell LE, O'Regan GM, McLean WH, Irvine AD, Kezic S, Sandilands A. Thawer-Esmail F, et al. J Allergy Clin Immunol. 2014 Jan;133(1):280-2.e1-2. doi: 10.1016/j.jaci.2013.09.053. J Allergy Clin Immunol. 2014. PMID: 24369804 Free PMC article. No abstract available.
Association between domestic water hardness, chlorine, and atopic dermatitis risk in early life: A population-based cross-sectional study.
Perkin MR, Craven J, Logan K, Strachan D, Marrs T, Radulovic S, Campbell LE, MacCallum SF, McLean WH, Lack G, Flohr C; Enquiring About Tolerance Study Team. Perkin MR, et al. J Allergy Clin Immunol. 2016 Aug;138(2):509-16. doi: 10.1016/j.jaci.2016.03.031. Epub 2016 Apr 28. J Allergy Clin Immunol. 2016. PMID: 27241890
Filaggrin null alleles are not associated with psoriasis.
Zhao Y, Terron-Kwiatkowski A, Liao H, Lee SP, Allen MH, Hull PR, Campbell LE, Trembath RC, Capon F, Griffiths CE, Burden D, McManus R, Hughes R, Kirby B, Rogers SF, Fitzgerald O, Kane D, Barker JN, Palmer CN, Irvine AD, McLean WH. Zhao Y, et al. J Invest Dermatol. 2007 Aug;127(8):1878-82. doi: 10.1038/sj.jid.5700817. Epub 2007 Apr 5. J Invest Dermatol. 2007. PMID: 17410197 Free article.
291 results