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Prostate apoptosis response-4 is expressed in normal cholangiocytes, is down-regulated in human cholangiocarcinoma, and promotes apoptosis of neoplastic cholangiocytes when induced pharmacologically.
Franchitto A, Torrice A, Semeraro R, Napoli C, Nuzzo G, Giuliante F, Alpini G, Carpino G, Berloco PB, Izzo L, Bolognese A, Onori P, Renzi A, Cantafora A, Gaudio E, Alvaro D. Franchitto A, et al. Among authors: renzi a. Am J Pathol. 2010 Oct;177(4):1779-90. doi: 10.2353/ajpath.2010.091171. Epub 2010 Aug 19. Am J Pathol. 2010. PMID: 20724592 Free PMC article.
Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors.
Renzi A, Glaser S, Demorrow S, Mancinelli R, Meng F, Franchitto A, Venter J, White M, Francis H, Han Y, Alvaro D, Gaudio E, Carpino G, Ueno Y, Onori P, Alpini G. Renzi A, et al. Am J Physiol Gastrointest Liver Physiol. 2011 Oct;301(4):G634-43. doi: 10.1152/ajpgi.00206.2011. Epub 2011 Jul 14. Am J Physiol Gastrointest Liver Physiol. 2011. PMID: 21757639 Free PMC article.
Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms.
Francis HL, Demorrow S, Franchitto A, Venter JK, Mancinelli RA, White MA, Meng F, Ueno Y, Carpino G, Renzi A, Baker KK, Shine HE, Francis TC, Gaudio E, Alpini GD, Onori P. Francis HL, et al. Among authors: renzi a. Lab Invest. 2012 Feb;92(2):282-94. doi: 10.1038/labinvest.2011.158. Epub 2011 Nov 7. Lab Invest. 2012. PMID: 22064319 Free PMC article.
Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis.
Han Y, Onori P, Meng F, DeMorrow S, Venter J, Francis H, Franchitto A, Ray D, Kennedy L, Greene J, Renzi A, Mancinelli R, Gaudio E, Glaser S, Alpini G. Han Y, et al. Among authors: renzi a. Am J Physiol Gastrointest Liver Physiol. 2014 Nov 1;307(9):G894-904. doi: 10.1152/ajpgi.00288.2014. Epub 2014 Sep 11. Am J Physiol Gastrointest Liver Physiol. 2014. PMID: 25214401 Free PMC article.
310 results