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Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.
Jiang M, Porat-Shliom Y, Pei Z, Cheng Y, Xiang L, Sommers K, Li Q, Gillardon F, Hengerer B, Berlinicke C, Smith WW, Zack DJ, Poirier MA, Ross CA, Duan W. Jiang M, et al. J Neurochem. 2010 Jul;114(2):419-29. doi: 10.1111/j.1471-4159.2010.06752.x. Epub 2010 Apr 19. J Neurochem. 2010. PMID: 20412383 Free PMC article.
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.
Jiang M, Wang J, Fu J, Du L, Jeong H, West T, Xiang L, Peng Q, Hou Z, Cai H, Seredenina T, Arbez N, Zhu S, Sommers K, Qian J, Zhang J, Mori S, Yang XW, Tamashiro KL, Aja S, Moran TH, Luthi-Carter R, Martin B, Maudsley S, Mattson MP, Cichewicz RH, Ross CA, Holtzman DM, Krainc D, Duan W. Jiang M, et al. Nat Med. 2011 Dec 18;18(1):153-8. doi: 10.1038/nm.2558. Nat Med. 2011. PMID: 22179319 Free PMC article.
Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
Waldron-Roby E, Ratovitski T, Wang X, Jiang M, Watkin E, Arbez N, Graham RK, Hayden MR, Hou Z, Mori S, Swing D, Pletnikov M, Duan W, Tessarollo L, Ross CA. Waldron-Roby E, et al. Among authors: jiang m. J Neurosci. 2012 Jan 4;32(1):183-93. doi: 10.1523/JNEUROSCI.1305-11.2012. J Neurosci. 2012. PMID: 22219281 Free PMC article.
trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease.
Fu J, Jin J, Cichewicz RH, Hageman SA, Ellis TK, Xiang L, Peng Q, Jiang M, Arbez N, Hotaling K, Ross CA, Duan W. Fu J, et al. Among authors: jiang m. J Biol Chem. 2012 Jul 13;287(29):24460-72. doi: 10.1074/jbc.M112.382226. Epub 2012 May 30. J Biol Chem. 2012. PMID: 22648412 Free PMC article.
Metabolism in HD: still a relevant mechanism?
Duan W, Jiang M, Jin J. Duan W, et al. Among authors: jiang m. Mov Disord. 2014 Sep 15;29(11):1366-74. doi: 10.1002/mds.25992. Epub 2014 Aug 13. Mov Disord. 2014. PMID: 25124273 Free PMC article. Review.
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