Ciancetta A - Search Results

1

Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists.

Tosh DK, Ciancetta A, Warnick E, O'Connor R, Chen Z, Gizewski E, Crane S, Gao ZG, Auchampach JA, Salvemini D, Jacobson KA. Tosh DK, et al. Among authors: ciancetta a. J Med Chem. 2016 Apr 14;59(7):3249-63. doi: 10.1021/acs.jmedchem.5b01998. Epub 2016 Feb 18. J Med Chem. 2016. PMID: 26890707 Free PMC article.

2

Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists.

Junker A, Balasubramanian R, Ciancetta A, Uliassi E, Kiselev E, Martiriggiano C, Trujillo K, Mtchedlidze G, Birdwell L, Brown KA, Harden TK, Jacobson KA. Junker A, et al. Among authors: ciancetta a. J Med Chem. 2016 Jul 14;59(13):6149-68. doi: 10.1021/acs.jmedchem.6b00044. Epub 2016 Jun 22. J Med Chem. 2016. PMID: 27331270 Free PMC article.

3

South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase.

Toti KS, Osborne D, Ciancetta A, Boison D, Jacobson KA. Toti KS, et al. Among authors: ciancetta a. J Med Chem. 2016 Jul 28;59(14):6860-77. doi: 10.1021/acs.jmedchem.6b00689. Epub 2016 Jul 13. J Med Chem. 2016. PMID: 27410258 Free PMC article.

4

Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT_2B/5HT_2C Serotonin Receptor Antagonists.

Tosh DK, Ciancetta A, Warnick E, Crane S, Gao ZG, Jacobson KA. Tosh DK, et al. Among authors: ciancetta a. J Med Chem. 2016 Dec 22;59(24):11006-11026. doi: 10.1021/acs.jmedchem.6b01183. Epub 2016 Dec 9. J Med Chem. 2016. PMID: 27933810 Free PMC article.

5

Structural Probing and Molecular Modeling of the A₃ Adenosine Receptor: A Focus on Agonist Binding.

Ciancetta A, Jacobson KA. Ciancetta A, et al. Molecules. 2017 Mar 11;22(3):449. doi: 10.3390/molecules22030449. Molecules. 2017. PMID: 28287473 Free PMC article. Review.

6

A₃ Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy.

Jacobson KA, Merighi S, Varani K, Borea PA, Baraldi S, Aghazadeh Tabrizi M, Romagnoli R, Baraldi PG, Ciancetta A, Tosh DK, Gao ZG, Gessi S. Jacobson KA, et al. Among authors: ciancetta a. Med Res Rev. 2018 Jul;38(4):1031-1072. doi: 10.1002/med.21456. Epub 2017 Jul 6. Med Res Rev. 2018. PMID: 28682469 Free PMC article. Review.

7

Structure-Guided Modification of Heterocyclic Antagonists of the P2Y₁₄ Receptor.

Yu J, Ciancetta A, Dudas S, Duca S, Lottermoser J, Jacobson KA. Yu J, et al. Among authors: ciancetta a. J Med Chem. 2018 Jun 14;61(11):4860-4882. doi: 10.1021/acs.jmedchem.8b00168. Epub 2018 May 16. J Med Chem. 2018. PMID: 29767967 Free PMC article.

8

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists.

Tosh DK, Ciancetta A, Mannes P, Warnick E, Janowsky A, Eshleman AJ, Gizewski E, Brust TF, Bohn LM, Auchampach JA, Gao ZG, Jacobson KA. Tosh DK, et al. Among authors: ciancetta a. ACS Omega. 2018 Oct 31;3(10):12658-12678. doi: 10.1021/acsomega.8b01237. Epub 2018 Oct 4. ACS Omega. 2018. PMID: 30411015 Free PMC article.

9

Design and in Vivo Characterization of A₁ Adenosine Receptor Agonists in the Native Ribose and Conformationally Constrained (N)-Methanocarba Series.

Tosh DK, Rao H, Bitant A, Salmaso V, Mannes P, Lieberman DI, Vaughan KL, Mattison JA, Rothwell AC, Auchampach JA, Ciancetta A, Liu N, Cui Z, Gao ZG, Reitman ML, Gavrilova O, Jacobson KA. Tosh DK, et al. Among authors: ciancetta a. J Med Chem. 2019 Feb 14;62(3):1502-1522. doi: 10.1021/acs.jmedchem.8b01662. Epub 2019 Jan 3. J Med Chem. 2019. PMID: 30605331 Free PMC article.

10

Polypharmacology of conformationally locked methanocarba nucleosides.

Jacobson KA, Tosh DK, Toti KS, Ciancetta A. Jacobson KA, et al. Among authors: ciancetta a. Drug Discov Today. 2017 Dec;22(12):1782-1791. doi: 10.1016/j.drudis.2017.07.013. Epub 2017 Aug 3. Drug Discov Today. 2017. PMID: 28781163 Free PMC article. Review.

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