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Time Courses of Cortical Glucose Metabolism and Microglial Activity Across the Life Span of Wild-Type Mice: A PET Study.
Brendel M, Focke C, Blume T, Peters F, Deussing M, Probst F, Jaworska A, Overhoff F, Albert N, Lindner S, von Ungern-Sternberg B, Bartenstein P, Haass C, Kleinberger G, Herms J, Rominger A. Brendel M, et al. Among authors: kleinberger g. J Nucl Med. 2017 Dec;58(12):1984-1990. doi: 10.2967/jnumed.117.195107. Epub 2017 Jul 13. J Nucl Med. 2017. PMID: 28705919 Free article.
Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice.
Focke C, Blume T, Zott B, Shi Y, Deussing M, Peters F, Schmidt C, Kleinberger G, Lindner S, Gildehaus FJ, Beyer L, von Ungern-Sternberg B, Bartenstein P, Ozmen L, Baumann K, Dorostkar MM, Haass C, Adelsberger H, Herms J, Rominger A, Brendel M. Focke C, et al. Among authors: kleinberger g. J Nucl Med. 2019 Apr;60(4):548-554. doi: 10.2967/jnumed.118.217703. Epub 2018 Sep 27. J Nucl Med. 2019. PMID: 30262517 Free article.
Asymmetry of Fibrillar Plaque Burden in Amyloid Mouse Models.
Sacher C, Blume T, Beyer L, Biechele G, Sauerbeck J, Eckenweber F, Deussing M, Focke C, Parhizkar S, Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Baumann K, Tahirovic S, Kleinberger G, Willem M, Haass C, Bartenstein P, Cumming P, Rominger A, Herms J, Brendel M. Sacher C, et al. Among authors: kleinberger g. J Nucl Med. 2020 Dec;61(12):1825-1831. doi: 10.2967/jnumed.120.242750. Epub 2020 May 15. J Nucl Med. 2020. PMID: 32414948 Free article.
Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation.
Biechele G, Blume T, Deussing M, Zott B, Shi Y, Xiang X, Franzmeier N, Kleinberger G, Peters F, Ochs K, Focke C, Sacher C, Wind K, Schmidt C, Lindner S, Gildehaus FJ, Eckenweber F, Beyer L, von Ungern-Sternberg B, Bartenstein P, Baumann K, Dorostkar MM, Rominger A, Cumming P, Willem M, Adelsberger H, Herms J, Brendel M. Biechele G, et al. Among authors: kleinberger g. Theranostics. 2021 Aug 19;11(18):8964-8976. doi: 10.7150/thno.64022. eCollection 2021. Theranostics. 2021. PMID: 34522221 Free PMC article.
Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis.
Brendel M, Kleinberger G, Probst F, Jaworska A, Overhoff F, Blume T, Albert NL, Carlsen J, Lindner S, Gildehaus FJ, Ozmen L, Suárez-Calvet M, Bartenstein P, Baumann K, Ewers M, Herms J, Haass C, Rominger A. Brendel M, et al. Among authors: kleinberger g. Front Aging Neurosci. 2017 Jan 31;9:8. doi: 10.3389/fnagi.2017.00008. eCollection 2017. Front Aging Neurosci. 2017. PMID: 28197095 Free PMC article.
The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.
Kleinberger G, Brendel M, Mracsko E, Wefers B, Groeneweg L, Xiang X, Focke C, Deußing M, Suárez-Calvet M, Mazaheri F, Parhizkar S, Pettkus N, Wurst W, Feederle R, Bartenstein P, Mueggler T, Arzberger T, Knuesel I, Rominger A, Haass C. Kleinberger G, et al. EMBO J. 2017 Jul 3;36(13):1837-1853. doi: 10.15252/embj.201796516. Epub 2017 May 30. EMBO J. 2017. PMID: 28559417 Free PMC article.
Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.
Götzl JK, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, Colombo AV, Deussing M, Wagner M, Winkelmann J, Diehl-Schmid J, Levin J, Fellerer K, Reifschneider A, Bultmann S, Bartenstein P, Rominger A, Tahirovic S, Smith ST, Madore C, Butovsky O, Capell A, Haass C. Götzl JK, et al. Among authors: kleinberger g. EMBO Mol Med. 2019 Jun;11(6):e9711. doi: 10.15252/emmm.201809711. EMBO Mol Med. 2019. PMID: 31122931 Free PMC article.
Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation.
Ewers M, Biechele G, Suárez-Calvet M, Sacher C, Blume T, Morenas-Rodriguez E, Deming Y, Piccio L, Cruchaga C, Kleinberger G, Shaw L, Trojanowski JQ, Herms J, Dichgans M; Alzheimer's Disease Neuroimaging Initiative (ADNI); Brendel M, Haass C, Franzmeier N. Ewers M, et al. Among authors: kleinberger g. EMBO Mol Med. 2020 Sep 7;12(9):e12308. doi: 10.15252/emmm.202012308. Epub 2020 Aug 10. EMBO Mol Med. 2020. PMID: 32790063 Free PMC article.
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, Tahirovic S, Herms J, Willem M, Pettkus N, Butovsky O, Bartenstein P, Edbauer D, Rominger A, Ertürk A, Grathwohl SA, Neher JJ, Holtzman DM, Meyer-Luehmann M, Haass C. Parhizkar S, et al. Among authors: kleinberger g. Nat Neurosci. 2019 Feb;22(2):191-204. doi: 10.1038/s41593-018-0296-9. Epub 2019 Jan 7. Nat Neurosci. 2019. PMID: 30617257 Free PMC article.
174 results