Greenlee W - Search Results

1

Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates.

Mandal M, Wu Y, Misiaszek J, Li G, Buevich A, Caldwell JP, Liu X, Mazzola RD, Orth P, Strickland C, Voigt J, Wang H, Zhu Z, Chen X, Grzelak M, Hyde LA, Kuvelkar R, Leach PT, Terracina G, Zhang L, Zhang Q, Michener MS, Smith B, Cox K, Grotz D, Favreau L, Mitra K, Kazakevich I, McKittrick BA, Greenlee W, Kennedy ME, Parker EM, Cumming JN, Stamford AW. Mandal M, et al. Among authors: greenlee w. J Med Chem. 2016 Apr 14;59(7):3231-48. doi: 10.1021/acs.jmedchem.5b01995. Epub 2016 Mar 22. J Med Chem. 2016. PMID: 26937601

2

Inhibitors of human renin with C-termini derived from amides and esters of alpha-mercaptoalkanoic acids.

Ashton WT, Cantone CL, Tolman RL, Greenlee WJ, Lynch RJ, Schorn TW, Strouse JF, Siegl PK. Ashton WT, et al. Among authors: greenlee wj. J Med Chem. 1992 Jul 24;35(15):2772-81. doi: 10.1021/jm00093a009. J Med Chem. 1992. PMID: 1495010

3

Synthesis and use of 3-amino-4-phenyl-2-piperidones and 4-amino-2-benzazepin-3-ones as conformationally restricted phenylalanine isosteres in renin inhibitors.

de Laszlo SE, Bush BL, Doyle JJ, Greenlee WJ, Hangauer DG, Halgren TA, Lynch RJ, Schorn TW, Siegl PK. de Laszlo SE, et al. Among authors: greenlee wj. J Med Chem. 1992 Mar 6;35(5):833-46. doi: 10.1021/jm00083a006. J Med Chem. 1992. PMID: 1548675

4

Renin inhibitors containing C-termini derived from mercaptoheterocycles.

Ashton WT, Cantone CL, Meurer LC, Tolman RL, Greenlee WJ, Patchett AA, Lynch RJ, Schorn TW, Strouse JF, Siegl PK. Ashton WT, et al. Among authors: greenlee wj. J Med Chem. 1992 May 29;35(11):2103-12. doi: 10.1021/jm00089a023. J Med Chem. 1992. PMID: 1597860

5

Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors.

Weber AE, Halgren TA, Doyle JJ, Lynch RJ, Siegl PK, Parsons WH, Greenlee WJ, Patchett AA. Weber AE, et al. Among authors: greenlee wj. J Med Chem. 1991 Sep;34(9):2692-701. doi: 10.1021/jm00113a005. J Med Chem. 1991. PMID: 1895289

6

(3-Amino-2-oxoalkyl)phosphonic acids and their analogues as novel inhibitors of D-alanine:D-alanine ligase.

Chakravarty PK, Greenlee WJ, Parsons WH, Patchett AA, Combs P, Roth A, Busch RD, Mellin TN. Chakravarty PK, et al. Among authors: greenlee wj. J Med Chem. 1989 Aug;32(8):1886-90. doi: 10.1021/jm00128a033. J Med Chem. 1989. PMID: 2502630

7

5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.

Williams TM, Ciccarone TM, MacTough SC, Rooney CS, Balani SK, Condra JH, Emini EA, Goldman ME, Greenlee WJ, Kauffman LR, et al. Williams TM, et al. Among authors: greenlee wj. J Med Chem. 1993 Apr 30;36(9):1291-4. doi: 10.1021/jm00061a022. J Med Chem. 1993. PMID: 7683725

8

Triazolinone biphenylsulfonamide derivatives as orally active angiotensin II antagonists with potent AT1 receptor affinity and enhanced AT2 affinity.

Ashton WT, Chang LL, Flanagan KL, Hutchins SM, Naylor EM, Chakravarty PK, Patchett AA, Greenlee WJ, Chen TB, Faust KA, et al. Ashton WT, et al. Among authors: greenlee wj. J Med Chem. 1994 Aug 19;37(17):2808-24. doi: 10.1021/jm00043a020. J Med Chem. 1994. PMID: 8064808

9

A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor.

de Laszlo SE, Quagliato CS, Greenlee WJ, Patchett AA, Chang RS, Lotti VJ, Chen TB, Scheck SA, Faust KA, Kivlighn SS, et al. de Laszlo SE, et al. Among authors: greenlee wj. J Med Chem. 1993 Oct 15;36(21):3207-10. doi: 10.1021/jm00073a024. J Med Chem. 1993. PMID: 8230109 No abstract available.

10

Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates.

Ashton WT, Hutchins SM, Greenlee WJ, Doss GA, Chang RS, Lotti VJ, Faust KA, Chen TB, Zingaro GJ, Kivlighn SD, et al. Ashton WT, et al. Among authors: greenlee wj. J Med Chem. 1993 Nov 12;36(23):3595-605. doi: 10.1021/jm00075a014. J Med Chem. 1993. PMID: 8246227

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