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Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1.
Christensen PM, Liu CH, Swendeman SL, Obinata H, Qvortrup K, Nielsen LB, Hla T, Di Lorenzo A, Christoffersen C. Christensen PM, et al. Among authors: obinata h. FASEB J. 2016 Jun;30(6):2351-9. doi: 10.1096/fj.201500064. Epub 2016 Mar 8. FASEB J. 2016. PMID: 26956418 Free PMC article.
The study suggests that vascular leakage of albumin-sized particles in ApoM deficiency is S1P- and S1P1-dependent and this dependency exacerbates the response to inflammatory stimuli.-Christensen, P. M., Liu, C. H., Swendeman, S. L., Obinata, H., Qvortrup, K. …
The study suggests that vascular leakage of albumin-sized particles in ApoM deficiency is S1P- and S1P1-dependent and this dependency exacer …
Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M.
Christoffersen C, Obinata H, Kumaraswamy SB, Galvani S, Ahnström J, Sevvana M, Egerer-Sieber C, Muller YA, Hla T, Nielsen LB, Dahlbäck B. Christoffersen C, et al. Among authors: obinata h. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9613-8. doi: 10.1073/pnas.1103187108. Epub 2011 May 23. Proc Natl Acad Sci U S A. 2011. PMID: 21606363 Free PMC article.
Sphingosine 1-phosphate in coagulation and inflammation.
Obinata H, Hla T. Obinata H, et al. Semin Immunopathol. 2012 Jan;34(1):73-91. doi: 10.1007/s00281-011-0287-3. Epub 2011 Jul 31. Semin Immunopathol. 2012. PMID: 21805322 Free PMC article. Review.
Fine-tuning S1P therapeutics.
Obinata H, Hla T. Obinata H, et al. Chem Biol. 2012 Sep 21;19(9):1080-2. doi: 10.1016/j.chembiol.2012.09.002. Chem Biol. 2012. PMID: 22999874 Free PMC article.
An engineered S1P chaperone attenuates hypertension and ischemic injury.
Swendeman SL, Xiong Y, Cantalupo A, Yuan H, Burg N, Hisano Y, Cartier A, Liu CH, Engelbrecht E, Blaho V, Zhang Y, Yanagida K, Galvani S, Obinata H, Salmon JE, Sanchez T, Di Lorenzo A, Hla T. Swendeman SL, et al. Among authors: obinata h. Sci Signal. 2017 Aug 15;10(492):eaal2722. doi: 10.1126/scisignal.aal2722. Sci Signal. 2017. PMID: 28811382 Free PMC article.
80 results