Di Paolo J - Search Results

1

Phase 2 study of idelalisib and entospletinib: pneumonitis limits combination therapy in relapsed refractory CLL and NHL.

Barr PM, Saylors GB, Spurgeon SE, Cheson BD, Greenwald DR, O'Brien SM, Liem AK, Mclntyre RE, Joshi A, Abella-Dominicis E, Hawkins MJ, Reddy A, Di Paolo J, Lee H, He J, Hu J, Dreiling LK, Friedberg JW. Barr PM, et al. Among authors: di paolo j. Blood. 2016 May 19;127(20):2411-5. doi: 10.1182/blood-2015-12-683516. Epub 2016 Mar 11. Blood. 2016. PMID: 26968534 Free PMC article. Clinical Trial.

2

A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor.

Burke RT, Meadows S, Loriaux MM, Currie KS, Mitchell SA, Maciejewski P, Clarke AS, Dipaolo JA, Druker BJ, Lannutti BJ, Spurgeon SE. Burke RT, et al. Oncotarget. 2014 Feb 28;5(4):908-15. doi: 10.18632/oncotarget.1484. Oncotarget. 2014. PMID: 24659719 Free PMC article.

3

SYK inhibitor entospletinib prevents ocular and skin GVHD in mice.

Poe JC, Jia W, Di Paolo JA, Reyes NJ, Kim JY, Su H, Sundy JS, Cardones AR, Perez VL, Chen BJ, Chao NJ, Cardona DM, Saban DR, Sarantopoulos S. Poe JC, et al. Among authors: di paolo ja. JCI Insight. 2018 Oct 4;3(19):e122430. doi: 10.1172/jci.insight.122430. JCI Insight. 2018. PMID: 30282825 Free PMC article.

4

Pharmacokinetics, Pharmacodynamics, and Safety of Entospletinib, a Novel pSYK Inhibitor, Following Single and Multiple Oral Dosing in Healthy Volunteers.

Ramanathan S, Di Paolo JA, Jin F, Shao L, Sharma S, Robeson M, Kearney BP. Ramanathan S, et al. Clin Drug Investig. 2017 Feb;37(2):195-205. doi: 10.1007/s40261-016-0476-x. Clin Drug Investig. 2017. PMID: 27785737 Free PMC article. Clinical Trial.

5

Targeting B-cell receptor signaling kinases in chronic lymphocytic leukemia: the promise of entospletinib.

Sharman J, Di Paolo J. Sharman J, et al. Among authors: di paolo j. Ther Adv Hematol. 2016 Jun;7(3):157-70. doi: 10.1177/2040620716636542. Epub 2016 Mar 17. Ther Adv Hematol. 2016. PMID: 27247756 Free PMC article. Review.

6

Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.

Currie KS, Kropf JE, Lee T, Blomgren P, Xu J, Zhao Z, Gallion S, Whitney JA, Maclin D, Lansdon EB, Maciejewski P, Rossi AM, Rong H, Macaluso J, Barbosa J, Di Paolo JA, Mitchell SA. Currie KS, et al. Among authors: di paolo ja. J Med Chem. 2014 May 8;57(9):3856-73. doi: 10.1021/jm500228a. Epub 2014 Apr 29. J Med Chem. 2014. PMID: 24779514

7

Effects of GS-9876, a novel spleen tyrosine kinase inhibitor, on platelet function and systemic hemostasis.

Clarke AS, Rousseau E, Wang K, Kim JY, Murray BP, Bannister R, Matzkies F, Currie KS, Di Paolo JA. Clarke AS, et al. Thromb Res. 2018 Oct;170:109-118. doi: 10.1016/j.thromres.2018.08.012. Epub 2018 Aug 23. Thromb Res. 2018. PMID: 30172129

8

Inhibition of Spleen Tyrosine Kinase Reduces Renal Allograft Injury in a Rat Model of Acute Antibody-Mediated Rejection in Sensitized Recipients.

Ramessur Chandran S, Han Y, Tesch GH, Di Paolo J, Mulley WR, Kanellis J, Ma FY, Nikolic-Paterson DJ. Ramessur Chandran S, et al. Among authors: di paolo j. Transplantation. 2017 Aug;101(8):e240-e248. doi: 10.1097/TP.0000000000001826. Transplantation. 2017. PMID: 28594748

9

B-cell receptor signaling inhibitors for treatment of autoimmune inflammatory diseases and B-cell malignancies.

Puri KD, Di Paolo JA, Gold MR. Puri KD, et al. Int Rev Immunol. 2013 Aug;32(4):397-427. doi: 10.3109/08830185.2013.818140. Int Rev Immunol. 2013. PMID: 23886342 Review.

10

Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis.

Nygaard G, Di Paolo JA, Hammaker D, Boyle DL, Budas G, Notte GT, Mikaelian I, Barry V, Firestein GS. Nygaard G, et al. Biochem Pharmacol. 2018 May;151:282-290. doi: 10.1016/j.bcp.2018.01.041. Epub 2018 Feb 6. Biochem Pharmacol. 2018. PMID: 29408488

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