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Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival.
Gastroenterology. 2016 Jul;151(1):180-193.e12. doi: 10.1053/j.gastro.2016.03.010. Epub 2016 Mar 19.
Gastroenterology. 2016.
PMID: 27003603
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.
Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, Yoshimura A, Reindl W, Sipos B, Akira S, Schmid RM, Algül H.
Lesina M, et al. Among authors: kurkowski mu.
Cancer Cell. 2011 Apr 12;19(4):456-69. doi: 10.1016/j.ccr.2011.03.009.
Cancer Cell. 2011.
PMID: 21481788
Free article.
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IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality.
Zhang H, Neuhöfer P, Song L, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regnér S, Thorlacius H, Saur D, Weirich G, Yoshimura A, Halangk W, Mizgerd JP, Schmid RM, Rose-John S, Algül H.
Zhang H, et al. Among authors: kurkowski mu.
J Clin Invest. 2013 Mar;123(3):1019-31. doi: 10.1172/JCI64931. Epub 2013 Feb 15.
J Clin Invest. 2013.
PMID: 23426178
Free PMC article.
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Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia.
Demir IE, Tieftrunk E, Schorn S, Saricaoglu ÖC, Pfitzinger PL, Teller S, Wang K, Waldbaur C, Kurkowski MU, Wörmann SM, Shaw VE, Kehl T, Laschinger M, Costello E, Algül H, Friess H, Ceyhan GO.
Demir IE, et al. Among authors: kurkowski mu.
Gut. 2016 Jun;65(6):1001-14. doi: 10.1136/gutjnl-2015-309784. Epub 2016 Jan 13.
Gut. 2016.
PMID: 26762195
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Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells.
Demir IE, Kujundzic K, Pfitzinger PL, Saricaoglu ÖC, Teller S, Kehl T, Reyes CM, Ertl LS, Miao Z, Schall TJ, Tieftrunk E, Haller B, Diakopoulos KN, Kurkowski MU, Lesina M, Krüger A, Algül H, Friess H, Ceyhan GO.
Demir IE, et al. Among authors: kurkowski mu.
Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):E85-E94. doi: 10.1073/pnas.1606909114. Epub 2016 Dec 16.
Proc Natl Acad Sci U S A. 2017.
PMID: 27986950
Free PMC article.
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