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Adenovirus type 35-vectored tuberculosis vaccine has an acceptable safety and tolerability profile in healthy, BCG-vaccinated, QuantiFERON(®)-TB Gold (+) Kenyan adults without evidence of tuberculosis.
Walsh DS, Owira V, Polhemus M, Otieno L, Andagalu B, Ogutu B, Waitumbi J, Hawkridge A, Shepherd B, Pau MG, Sadoff J, Douoguih M, McClain JB; Aeras C-012-402 Study Team. Walsh DS, et al. Among authors: hawkridge a. Vaccine. 2016 May 5;34(21):2430-2436. doi: 10.1016/j.vaccine.2016.03.069. Epub 2016 Mar 26. Vaccine. 2016. PMID: 27026148 Free article. Clinical Trial.
Dose-dependent immune response to Mycobacterium bovis BCG vaccination in neonates.
Davids V, Hanekom W, Gelderbloem SJ, Hawkridge A, Hussey G, Sheperd R, Workman L, Soler J, Murray RA, Ress SR, Kaplan G. Davids V, et al. Among authors: hawkridge a. Clin Vaccine Immunol. 2007 Feb;14(2):198-200. doi: 10.1128/CVI.00309-06. Epub 2006 Dec 20. Clin Vaccine Immunol. 2007. PMID: 17182761 Free PMC article.
Clinical studies of TB vaccines.
Hawkridge A. Hawkridge A. Hum Vaccin. 2009 Nov;5(11):773-6. doi: 10.4161/hv.5.11.9310. Epub 2009 Nov 22. Hum Vaccin. 2009. PMID: 19684467 Review.
Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells.
Scriba TJ, Tameris M, Mansoor N, Smit E, van der Merwe L, Isaacs F, Keyser A, Moyo S, Brittain N, Lawrie A, Gelderbloem S, Veldsman A, Hatherill M, Hawkridge A, Hill AV, Hussey GD, Mahomed H, McShane H, Hanekom WA. Scriba TJ, et al. Among authors: hawkridge a. Eur J Immunol. 2010 Jan;40(1):279-90. doi: 10.1002/eji.200939754. Eur J Immunol. 2010. PMID: 20017188 Free PMC article. Clinical Trial.
The novel tuberculosis vaccine, AERAS-402, induces robust and polyfunctional CD4+ and CD8+ T cells in adults.
Abel B, Tameris M, Mansoor N, Gelderbloem S, Hughes J, Abrahams D, Makhethe L, Erasmus M, de Kock M, van der Merwe L, Hawkridge A, Veldsman A, Hatherill M, Schirru G, Pau MG, Hendriks J, Weverling GJ, Goudsmit J, Sizemore D, McClain JB, Goetz M, Gearhart J, Mahomed H, Hussey GD, Sadoff JC, Hanekom WA. Abel B, et al. Among authors: hawkridge a. Am J Respir Crit Care Med. 2010 Jun 15;181(12):1407-17. doi: 10.1164/rccm.200910-1484OC. Epub 2010 Feb 18. Am J Respir Crit Care Med. 2010. PMID: 20167847 Free PMC article. Clinical Trial.
Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newborns.
Kagina BM, Abel B, Scriba TJ, Hughes EJ, Keyser A, Soares A, Gamieldien H, Sidibana M, Hatherill M, Gelderbloem S, Mahomed H, Hawkridge A, Hussey G, Kaplan G, Hanekom WA; other members of the South African Tuberculosis Vaccine Initiative. Kagina BM, et al. Among authors: hawkridge a. Am J Respir Crit Care Med. 2010 Oct 15;182(8):1073-9. doi: 10.1164/rccm.201003-0334OC. Epub 2010 Jun 17. Am J Respir Crit Care Med. 2010. PMID: 20558627 Free PMC article.
Induction and regulation of T-cell immunity by the novel tuberculosis vaccine M72/AS01 in South African adults.
Day CL, Tameris M, Mansoor N, van Rooyen M, de Kock M, Geldenhuys H, Erasmus M, Makhethe L, Hughes EJ, Gelderbloem S, Bollaerts A, Bourguignon P, Cohen J, Demoitié MA, Mettens P, Moris P, Sadoff JC, Hawkridge A, Hussey GD, Mahomed H, Ofori-Anyinam O, Hanekom WA. Day CL, et al. Among authors: hawkridge a. Am J Respir Crit Care Med. 2013 Aug 15;188(4):492-502. doi: 10.1164/rccm.201208-1385OC. Am J Respir Crit Care Med. 2013. PMID: 23306546 Free PMC article. Clinical Trial.
92 results