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Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects.
Millar JS, Reyes-Soffer G, Jumes P, Dunbar RL, deGoma EM, Baer AL, Karmally W, Donovan DS, Rafeek H, Pollan L, Tohyama J, Johnson-Levonas AO, Wagner JA, Holleran S, Obunike J, Liu Y, Ramakrishnan R, Lassman ME, Gutstein DE, Ginsberg HN, Rader DJ. Millar JS, et al. Among authors: obunike j. J Clin Invest. 2016 Apr 1;126(4):1603-4. doi: 10.1172/JCI87364. Epub 2016 Apr 1. J Clin Invest. 2016. PMID: 27035815 Free PMC article. No abstract available.
Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects.
Millar JS, Reyes-Soffer G, Jumes P, Dunbar RL, deGoma EM, Baer AL, Karmally W, Donovan DS, Rafeek H, Pollan L, Tohyama J, Johnson-Levonas AO, Wagner JA, Holleran S, Obunike J, Liu Y, Ramakrishnan R, Lassman ME, Gutstein DE, Ginsberg HN, Rader DJ. Millar JS, et al. Among authors: obunike j. J Clin Invest. 2015 Jun;125(6):2510-22. doi: 10.1172/JCI80025. Epub 2015 May 11. J Clin Invest. 2015. PMID: 25961461 Free PMC article. Clinical Trial.
Effects of CETP inhibition with anacetrapib on metabolism of VLDL-TG and plasma apolipoproteins C-II, C-III, and E.
Millar JS, Lassman ME, Thomas T, Ramakrishnan R, Jumes P, Dunbar RL, deGoma EM, Baer AL, Karmally W, Donovan DS, Rafeek H, Wagner JA, Holleran S, Obunike J, Liu Y, Aoujil S, Standiford T, Gutstein DE, Ginsberg HN, Rader DJ, Reyes-Soffer G. Millar JS, et al. Among authors: obunike j. J Lipid Res. 2017 Jun;58(6):1214-1220. doi: 10.1194/jlr.M074880. Epub 2017 Mar 17. J Lipid Res. 2017. PMID: 28314859 Free PMC article.
Complex effects of inhibiting hepatic apolipoprotein B100 synthesis in humans.
Reyes-Soffer G, Moon B, Hernandez-Ono A, Dionizovik-Dimanovski M, Jimenez J, Obunike J, Thomas T, Ngai C, Fontanez N, Donovan DS, Karmally W, Holleran S, Ramakrishnan R, Mittleman RS, Ginsberg HN. Reyes-Soffer G, et al. Among authors: obunike j. Sci Transl Med. 2016 Jan 27;8(323):323ra12. doi: 10.1126/scitranslmed.aad2195. Sci Transl Med. 2016. PMID: 26819195 Free PMC article. Clinical Trial.
Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans.
Reyes-Soffer G, Pavlyha M, Ngai C, Thomas T, Holleran S, Ramakrishnan R, Karmally W, Nandakumar R, Fontanez N, Obunike J, Marcovina SM, Lichtenstein AH, Matthan NR, Matta J, Maroccia M, Becue F, Poitiers F, Swanson B, Cowan L, Sasiela WJ, Surks HK, Ginsberg HN. Reyes-Soffer G, et al. Among authors: obunike j. Circulation. 2017 Jan 24;135(4):352-362. doi: 10.1161/CIRCULATIONAHA.116.025253. Epub 2016 Dec 16. Circulation. 2017. PMID: 27986651 Free PMC article. Clinical Trial.
Adipose-specific lipoprotein lipase deficiency more profoundly affects brown than white fat biology.
Garcia-Arcos I, Hiyama Y, Drosatos K, Bharadwaj KG, Hu Y, Son NH, O'Byrne SM, Chang CL, Deckelbaum RJ, Takahashi M, Westerterp M, Obunike JC, Jiang H, Yagyu H, Blaner WS, Goldberg IJ. Garcia-Arcos I, et al. Among authors: obunike jc. J Biol Chem. 2013 May 17;288(20):14046-14058. doi: 10.1074/jbc.M113.469270. Epub 2013 Mar 31. J Biol Chem. 2013. PMID: 23542081 Free PMC article.
22 results