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Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.
Cancer Metab. 2016 Apr 1;4:6. doi: 10.1186/s40170-016-0146-8. eCollection 2016.
Cancer Metab. 2016.
PMID: 27042297
Free PMC article.
Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress.
Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K, McGarry L, James D, Shanks E, Kalna G, Saunders RE, Jiang M, Howell M, Lassailly F, Thin MZ, Spencer-Dene B, Stamp G, van den Broek NJ, Mackay G, Bulusu V, Kamphorst JJ, Tardito S, Strachan D, Harris AL, Aboagye EO, Critchlow SE, Wakelam MJ, Schulze A, Gottlieb E.
Schug ZT, et al. Among authors: smethurst e.
Cancer Cell. 2015 Jan 12;27(1):57-71. doi: 10.1016/j.ccell.2014.12.002.
Cancer Cell. 2015.
PMID: 25584894
Free PMC article.
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3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers.
Jones DT, Valli A, Haider S, Zhang Q, Smethurst EA, Schug ZT, Peck B, Aboagye EO, Critchlow SE, Schulze A, Gottlieb E, Wakelam MJO, Harris AL.
Jones DT, et al. Among authors: smethurst ea.
Mol Cancer Ther. 2019 Feb;18(2):376-388. doi: 10.1158/1535-7163.MCT-17-0857. Epub 2018 Nov 26.
Mol Cancer Ther. 2019.
PMID: 30478149
Free PMC article.
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The Phospholipase D2 Knock Out Mouse Has Ectopic Purkinje Cells and Suffers from Early Adult-Onset Anosmia.
Vermeren MM, Zhang Q, Smethurst E, Segonds-Pichon A, Schrewe H, Wakelam MJ.
Vermeren MM, et al. Among authors: smethurst e.
PLoS One. 2016 Sep 22;11(9):e0162814. doi: 10.1371/journal.pone.0162814. eCollection 2016.
PLoS One. 2016.
PMID: 27658289
Free PMC article.
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Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal.
Muinonen-Martin AJ, Susanto O, Zhang Q, Smethurst E, Faller WJ, Veltman DM, Kalna G, Lindsay C, Bennett DC, Sansom OJ, Herd R, Jones R, Machesky LM, Wakelam MJ, Knecht DA, Insall RH.
Muinonen-Martin AJ, et al. Among authors: smethurst e.
PLoS Biol. 2014 Oct 14;12(10):e1001966. doi: 10.1371/journal.pbio.1001966. eCollection 2014 Oct.
PLoS Biol. 2014.
PMID: 25313567
Free PMC article.
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EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2.
Nieminuszczy J, Broderick R, Bellani MA, Smethurst E, Schwab RA, Cherdyntseva V, Evmorfopoulou T, Lin YL, Minczuk M, Pasero P, Gagos S, Seidman MM, Niedzwiedz W.
Nieminuszczy J, et al. Among authors: smethurst e.
Mol Cell. 2019 Aug 8;75(3):605-619.e6. doi: 10.1016/j.molcel.2019.05.026. Epub 2019 Jun 26.
Mol Cell. 2019.
PMID: 31255466
Free PMC article.
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A new stainless steel alloy for surgical implants compared to 316 S12.
Smethurst E.
Smethurst E.
Biomaterials. 1981 Apr;2(2):116-9. doi: 10.1016/0142-9612(81)90009-0.
Biomaterials. 1981.
PMID: 7248423
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A physical examination of orthopaedic implants and asjacent tissue.
Smethurst E, Waterhouse RB.
Smethurst E, et al.
Acta Orthop Scand. 1978 Feb;49(1):8-18. doi: 10.3109/17453677809005717.
Acta Orthop Scand. 1978.
PMID: 654901
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