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Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?
Rugel AR, Guzman MA, Taylor AB, Chevalier FD, Tarpley RS, McHardy SF, Cao X, Holloway SP, Anderson TJC, Hart PJ, LoVerde PT. Rugel AR, et al. Int J Parasitol Drugs Drug Resist. 2020 Aug;13:8-15. doi: 10.1016/j.ijpddr.2020.04.001. Epub 2020 Apr 10. Int J Parasitol Drugs Drug Resist. 2020. PMID: 32315953 Free PMC article.
An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans.
Guzman MA, Rugel AR, Tarpley RS, Alwan SN, Chevalier FD, Kovalskyy DP, Cao X, Holloway SP, Anderson TJC, Taylor AB, McHardy SF, LoVerde PT. Guzman MA, et al. Among authors: rugel ar. PLoS Negl Trop Dis. 2020 Aug 18;14(8):e0008517. doi: 10.1371/journal.pntd.0008517. eCollection 2020 Aug. PLoS Negl Trop Dis. 2020. PMID: 32810153 Free PMC article.
Schistosome Sulfotransferases: Mode of Action, Expression and Localization.
Guzman MA, Rugel A, Alwan SN, Tarpley R, Taylor AB, Chevalier FD, Wendt GR, Collins JJ 3rd, Anderson TJC, McHardy SF, LoVerde PT. Guzman MA, et al. Pharmaceutics. 2022 Jul 6;14(7):1416. doi: 10.3390/pharmaceutics14071416. Pharmaceutics. 2022. PMID: 35890311 Free PMC article.