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Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells.
Guillem-Llobat P, Dovizio M, Bruno A, Ricciotti E, Cufino V, Sacco A, Grande R, Alberti S, Arena V, Cirillo M, Patrono C, FitzGerald GA, Steinhilber D, Sgambato A, Patrignani P. Guillem-Llobat P, et al. Among authors: sgambato a. Oncotarget. 2016 May 31;7(22):32462-77. doi: 10.18632/oncotarget.8655. Oncotarget. 2016. PMID: 27074574 Free PMC article.
Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells.
Dovizio M, Maier TJ, Alberti S, Di Francesco L, Marcantoni E, Münch G, John CM, Suess B, Sgambato A, Steinhilber D, Patrignani P. Dovizio M, et al. Among authors: sgambato a. Mol Pharmacol. 2013 Jul;84(1):25-40. doi: 10.1124/mol.113.084988. Epub 2013 Apr 11. Mol Pharmacol. 2013. PMID: 23580446 Free PMC article.
Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice.
Sacco A, Bruno A, Contursi A, Dovizio M, Tacconelli S, Ricciotti E, Guillem-Llobat P, Salvatore T, Di Francesco L, Fullone R, Ballerini P, Arena V, Alberti S, Liu G, Gong Y, Sgambato A, Patrono C, FitzGerald GA, Yu Y, Patrignani P. Sacco A, et al. Among authors: sgambato a. J Pharmacol Exp Ther. 2019 Sep;370(3):416-426. doi: 10.1124/jpet.119.259382. Epub 2019 Jun 27. J Pharmacol Exp Ther. 2019. PMID: 31248980
Locally injected Infliximab ameliorates murine DSS colitis: differences in serum and intestinal levels of drug between healthy and colitic mice.
Lopetuso LR, Petito V, Cufino V, Arena V, Stigliano E, Gerardi V, Gaetani E, Poscia A, Amato A, Cammarota G, Papa A, Sgambato A, Gasbarrini A, Scaldaferri F. Lopetuso LR, et al. Among authors: sgambato a. Dig Liver Dis. 2013 Dec;45(12):1017-21. doi: 10.1016/j.dld.2013.06.007. Epub 2013 Aug 2. Dig Liver Dis. 2013. PMID: 23911613
Infliximab does not increase colonic cancer risk associated to murine chronic colitis.
Lopetuso LR, Petito V, Zinicola T, Graziani C, Gerardi V, Arena V, Caristo ME, Poscia A, Cammarota G, Papa A, Cufino V, Sgambato A, Gasbarrini A, Scaldaferri F. Lopetuso LR, et al. Among authors: sgambato a. World J Gastroenterol. 2016 Nov 28;22(44):9727-9733. doi: 10.3748/wjg.v22.i44.9727. World J Gastroenterol. 2016. PMID: 27956796 Free PMC article.
IFN-α potentiates the direct and immune-mediated antitumor effects of epigenetic drugs on both metastatic and stem cells of colorectal cancer.
Buoncervello M, Romagnoli G, Buccarelli M, Fragale A, Toschi E, Parlato S, Lucchetti D, Macchia D, Spada M, Canini I, Sanchez M, Falchi M, Musella M, Biffoni M, Belardelli F, Capone I, Sgambato A, Vitiani LR, Gabriele L. Buoncervello M, et al. Among authors: sgambato a. Oncotarget. 2016 May 3;7(18):26361-73. doi: 10.18632/oncotarget.8379. Oncotarget. 2016. PMID: 27028869 Free PMC article.
287 results