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Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population.
Shimada-Sugimoto M, Otowa T, Miyagawa T, Khor SS, Omae Y, Toyo-Oka L, Sugaya N, Kawamura Y, Umekage T, Miyashita A, Kuwano R, Kaiya H, Kasai K, Tanii H, Okazaki Y, Tokunaga K, Sasaki T. Shimada-Sugimoto M, et al. Hum Genome Var. 2016 Feb 25;3:16001. doi: 10.1038/hgv.2016.1. eCollection 2016. Hum Genome Var. 2016. PMID: 27081567 Free PMC article.
Immune-related pathways including HLA-DRB1(∗)13:02 are associated with panic disorder.
Shimada-Sugimoto M, Otowa T, Miyagawa T, Khor SS, Kashiwase K, Sugaya N, Kawamura Y, Umekage T, Kojima H, Saji H, Miyashita A, Kuwano R, Kaiya H, Kasai K, Tanii H, Okazaki Y, Tokunaga K, Sasaki T. Shimada-Sugimoto M, et al. Brain Behav Immun. 2015 May;46:96-103. doi: 10.1016/j.bbi.2015.01.002. Epub 2015 Jan 9. Brain Behav Immun. 2015. PMID: 25582808
Epigenome-wide association study of DNA methylation in panic disorder.
Shimada-Sugimoto M, Otowa T, Miyagawa T, Umekage T, Kawamura Y, Bundo M, Iwamoto K, Tochigi M, Kasai K, Kaiya H, Tanii H, Okazaki Y, Tokunaga K, Sasaki T. Shimada-Sugimoto M, et al. Clin Epigenetics. 2017 Jan 21;9:6. doi: 10.1186/s13148-016-0307-1. eCollection 2017. Clin Epigenetics. 2017. PMID: 28149334 Free PMC article.
Whole-exome sequencing and gene-based rare variant association tests suggest that PLA2G4E might be a risk gene for panic disorder.
Morimoto Y, Shimada-Sugimoto M, Otowa T, Yoshida S, Kinoshita A, Mishima H, Yamaguchi N, Mori T, Imamura A, Ozawa H, Kurotaki N, Ziegler C, Domschke K, Deckert J, Umekage T, Tochigi M, Kaiya H, Okazaki Y, Tokunaga K, Sasaki T, Yoshiura KI, Ono S. Morimoto Y, et al. Among authors: shimada sugimoto m. Transl Psychiatry. 2018 Feb 2;8(1):41. doi: 10.1038/s41398-017-0088-0. Transl Psychiatry. 2018. PMID: 29391400 Free PMC article.