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Stretch-sensitive KCNQ1 mutation A link between genetic and environmental factors in the pathogenesis of atrial fibrillation?
Otway R, Vandenberg JI, Guo G, Varghese A, Castro ML, Liu J, Zhao J, Bursill JA, Wyse KR, Crotty H, Baddeley O, Walker B, Kuchar D, Thorburn C, Fatkin D. Otway R, et al. Among authors: vandenberg ji. J Am Coll Cardiol. 2007 Feb 6;49(5):578-86. doi: 10.1016/j.jacc.2006.09.044. Epub 2007 Jan 22. J Am Coll Cardiol. 2007. PMID: 17276182 Free article.
Genes and atrial fibrillation: a new look at an old problem.
Fatkin D, Otway R, Vandenberg JI. Fatkin D, et al. Among authors: vandenberg ji. Circulation. 2007 Aug 14;116(7):782-92. doi: 10.1161/CIRCULATIONAHA.106.688889. Circulation. 2007. PMID: 17698744 Review. No abstract available.
Atrial fibrillation--a new cardiac channelopathy.
Otway R, Vandenberg JI, Fatkin D. Otway R, et al. Among authors: vandenberg ji. Heart Lung Circ. 2007 Oct;16(5):356-60. doi: 10.1016/j.hlc.2007.07.003. Epub 2007 Sep 4. Heart Lung Circ. 2007. PMID: 17768091 Review.
Not all hERG pore domain mutations have a severe phenotype: G584S has an inactivation gating defect with mild phenotype compared to G572S, which has a dominant negative trafficking defect and a severe phenotype.
Zhao JT, Hill AP, Varghese A, Cooper AA, Swan H, Laitinen-Forsblom PJ, Rees MI, Skinner JR, Campbell TJ, Vandenberg JI. Zhao JT, et al. Among authors: vandenberg ji. J Cardiovasc Electrophysiol. 2009 Aug;20(8):923-30. doi: 10.1111/j.1540-8167.2009.01468.x. Epub 2009 Apr 10. J Cardiovasc Electrophysiol. 2009. PMID: 19490267
Epistatic effects of potassium channel variation on cardiac repolarization and atrial fibrillation risk.
Mann SA, Otway R, Guo G, Soka M, Karlsdotter L, Trivedi G, Ohanian M, Zodgekar P, Smith RA, Wouters MA, Subbiah R, Walker B, Kuchar D, Sanders P, Griffiths L, Vandenberg JI, Fatkin D. Mann SA, et al. Among authors: vandenberg ji. J Am Coll Cardiol. 2012 Mar 13;59(11):1017-25. doi: 10.1016/j.jacc.2011.11.039. J Am Coll Cardiol. 2012. PMID: 22402074 Free article.
Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.
Liang B, Soka M, Christensen AH, Olesen MS, Larsen AP, Knop FK, Wang F, Nielsen JB, Andersen MN, Humphreys D, Mann SA, Huttner IG, Vandenberg JI, Svendsen JH, Haunsø S, Preiss T, Seebohm G, Olesen SP, Schmitt N, Fatkin D. Liang B, et al. Among authors: vandenberg ji. J Mol Cell Cardiol. 2014 Feb;67:69-76. doi: 10.1016/j.yjmcc.2013.12.014. Epub 2013 Dec 27. J Mol Cell Cardiol. 2014. PMID: 24374141
Getting to the heart of hERG K(+) channel gating.
Perry MD, Ng CA, Mann SA, Sadrieh A, Imtiaz M, Hill AP, Vandenberg JI. Perry MD, et al. Among authors: vandenberg ji. J Physiol. 2015 Jun 15;593(12):2575-85. doi: 10.1113/JP270095. J Physiol. 2015. PMID: 25820318 Free PMC article. Review.
145 results