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Page 1
The MC1R Gene and Youthful Looks.
Liu F, Hamer MA, Deelen J, Lall JS, Jacobs L, van Heemst D, Murray PG, Wollstein A, de Craen AJ, Uh HW, Zeng C, Hofman A, Uitterlinden AG, Houwing-Duistermaat JJ, Pardo LM, Beekman M, Slagboom PE, Nijsten T, Kayser M, Gunn DA. Liu F, et al. Among authors: de craen aj. Curr Biol. 2016 May 9;26(9):1213-20. doi: 10.1016/j.cub.2016.03.008. Epub 2016 Apr 28. Curr Biol. 2016. PMID: 27133870 Free article.
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Deelen J, Beekman M, Uh HW, Helmer Q, Kuningas M, Christiansen L, Kremer D, van der Breggen R, Suchiman HE, Lakenberg N, van den Akker EB, Passtoors WM, Tiemeier H, van Heemst D, de Craen AJ, Rivadeneira F, de Geus EJ, Perola M, van der Ouderaa FJ, Gunn DA, Boomsma DI, Uitterlinden AG, Christensen K, van Duijn CM, Heijmans BT, Houwing-Duistermaat JJ, Westendorp RG, Slagboom PE. Deelen J, et al. Among authors: de craen aj, de geus ej. Aging Cell. 2011 Aug;10(4):686-98. doi: 10.1111/j.1474-9726.2011.00705.x. Epub 2011 May 6. Aging Cell. 2011. PMID: 21418511 Free PMC article.
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity.
Beekman M, Nederstigt C, Suchiman HE, Kremer D, van der Breggen R, Lakenberg N, Alemayehu WG, de Craen AJ, Westendorp RG, Boomsma DI, de Geus EJ, Houwing-Duistermaat JJ, Heijmans BT, Slagboom PE. Beekman M, et al. Among authors: de craen aj, de geus ej. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18046-9. doi: 10.1073/pnas.1003540107. Epub 2010 Oct 4. Proc Natl Acad Sci U S A. 2010. PMID: 20921414 Free PMC article.
High serum glucose levels are associated with a higher perceived age.
Noordam R, Gunn DA, Tomlin CC, Maier AB, Mooijaart SP, Slagboom PE, Westendorp RG, de Craen AJ, van Heemst D; Leiden Longevity Study Group. Noordam R, et al. Among authors: de craen aj. Age (Dordr). 2013 Feb;35(1):189-95. doi: 10.1007/s11357-011-9339-9. Epub 2011 Nov 20. Age (Dordr). 2013. PMID: 22102339 Free PMC article.
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.
Deelen J, Uh HW, Monajemi R, van Heemst D, Thijssen PE, Böhringer S, van den Akker EB, de Craen AJ, Rivadeneira F, Uitterlinden AG, Westendorp RG, Goeman JJ, Slagboom PE, Houwing-Duistermaat JJ, Beekman M. Deelen J, et al. Among authors: de craen aj. Age (Dordr). 2013 Feb;35(1):235-49. doi: 10.1007/s11357-011-9340-3. Epub 2011 Nov 24. Age (Dordr). 2013. PMID: 22113349 Free PMC article.
Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R.
Passtoors WM, Boer JM, Goeman JJ, Akker EB, Deelen J, Zwaan BJ, Scarborough A, Breggen Rv, Vossen RH, Houwing-Duistermaat JJ, Ommen GJ, Westendorp RG, van Heemst D, de Craen AJ, White AJ, Gunn DA, Beekman M, Slagboom PE. Passtoors WM, et al. Among authors: de craen aj. PLoS One. 2012;7(1):e27759. doi: 10.1371/journal.pone.0027759. Epub 2012 Jan 11. PLoS One. 2012. PMID: 22247756 Free PMC article.
The number of p16INK4a positive cells in human skin reflects biological age.
Waaijer ME, Parish WE, Strongitharm BH, van Heemst D, Slagboom PE, de Craen AJ, Sedivy JM, Westendorp RG, Gunn DA, Maier AB. Waaijer ME, et al. Among authors: de craen aj. Aging Cell. 2012 Aug;11(4):722-5. doi: 10.1111/j.1474-9726.2012.00837.x. Epub 2012 Jun 11. Aging Cell. 2012. PMID: 22612594 Free PMC article.
464 results