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High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation.
Mol Biol Cell. 2016 Jul 1;27(13):1981-9. doi: 10.1091/mbc.E15-10-0747. Epub 2016 May 4.
Mol Biol Cell. 2016.
PMID: 27146113
Free PMC article.
Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons.
Ryan SD, Britigan EM, Zasadil LM, Witte K, Audhya A, Roopra A, Weaver BA.
Ryan SD, et al. Among authors: britigan em.
Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):E2205-14. doi: 10.1073/pnas.1201911109. Epub 2012 Jul 9.
Proc Natl Acad Sci U S A. 2012.
PMID: 22778409
Free PMC article.
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2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells.
Zasadil LM, Britigan EM, Weaver BA.
Zasadil LM, et al. Among authors: britigan em.
Semin Cell Dev Biol. 2013 Apr;24(4):370-9. doi: 10.1016/j.semcdb.2013.02.001. Epub 2013 Feb 13.
Semin Cell Dev Biol. 2013.
PMID: 23416057
Free PMC article.
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The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B.
Britigan EM, Wan J, Zasadil LM, Ryan SD, Weaver BA.
Britigan EM, et al.
Mol Biol Cell. 2014 Sep 15;25(18):2761-73. doi: 10.1091/mbc.E14-05-0966. Epub 2014 Jul 23.
Mol Biol Cell. 2014.
PMID: 25057018
Free PMC article.
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Increased Aurora B expression reduces substrate phosphorylation and induces chromosomal instability.
Britigan EMC, Wan J, Sam DK, Copeland SE, Lasek AL, Hrycyniak LCF, Wang L, Audhya A, Burkard ME, Roopra A, Weaver BA.
Britigan EMC, et al.
Front Cell Dev Biol. 2022 Oct 13;10:1018161. doi: 10.3389/fcell.2022.1018161. eCollection 2022.
Front Cell Dev Biol. 2022.
PMID: 36313574
Free PMC article.
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