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Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures.
Wang X, Tucker NR, Rizki G, Mills R, Krijger PH, de Wit E, Subramanian V, Bartell E, Nguyen XX, Ye J, Leyton-Mange J, Dolmatova EV, van der Harst P, de Laat W, Ellinor PT, Newton-Cheh C, Milan DJ, Kellis M, Boyer LA. Wang X, et al. Among authors: de laat w, de wit e. Elife. 2016 May 10;5:e10557. doi: 10.7554/eLife.10557. Elife. 2016. PMID: 27162171 Free PMC article.
Variegated gene expression caused by cell-specific long-range DNA interactions.
Noordermeer D, de Wit E, Klous P, van de Werken H, Simonis M, Lopez-Jones M, Eussen B, de Klein A, Singer RH, de Laat W. Noordermeer D, et al. Among authors: de klein a, de laat w, de wit e. Nat Cell Biol. 2011 Jun 26;13(8):944-51. doi: 10.1038/ncb2278. Nat Cell Biol. 2011. PMID: 21706023 Free PMC article.
4C technology: protocols and data analysis.
van de Werken HJ, de Vree PJ, Splinter E, Holwerda SJ, Klous P, de Wit E, de Laat W. van de Werken HJ, et al. Among authors: de vree pj, de laat w, de wit e. Methods Enzymol. 2012;513:89-112. doi: 10.1016/B978-0-12-391938-0.00004-5. Methods Enzymol. 2012. PMID: 22929766
Robust 4C-seq data analysis to screen for regulatory DNA interactions.
van de Werken HJ, Landan G, Holwerda SJ, Hoichman M, Klous P, Chachik R, Splinter E, Valdes-Quezada C, Oz Y, Bouwman BA, Verstegen MJ, de Wit E, Tanay A, de Laat W. van de Werken HJ, et al. Among authors: de laat w, de wit e. Nat Methods. 2012 Oct;9(10):969-72. doi: 10.1038/nmeth.2173. Epub 2012 Sep 9. Nat Methods. 2012. PMID: 22961246
The pluripotent genome in three dimensions is shaped around pluripotency factors.
de Wit E, Bouwman BA, Zhu Y, Klous P, Splinter E, Verstegen MJ, Krijger PH, Festuccia N, Nora EP, Welling M, Heard E, Geijsen N, Poot RA, Chambers I, de Laat W. de Wit E, et al. Among authors: de laat w. Nature. 2013 Sep 12;501(7466):227-31. doi: 10.1038/nature12420. Epub 2013 Jul 24. Nature. 2013. PMID: 23883933
140 results