Duca J - Search Results

1

Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.

Touré BB, Giraldes J, Smith T, Sprague ER, Wang Y, Mathieu S, Chen Z, Mishina Y, Feng Y, Yan-Neale Y, Shakya S, Chen D, Meyer M, Puleo D, Brazell JT, Straub C, Sage D, Wright K, Yuan Y, Chen X, Duca J, Kim S, Tian L, Martin E, Hurov K, Shao W. Touré BB, et al. Among authors: duca j. J Med Chem. 2016 May 26;59(10):4711-23. doi: 10.1021/acs.jmedchem.6b00052. Epub 2016 May 17. J Med Chem. 2016. PMID: 27187609

2

"Addition" and "Subtraction": Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase Inhibitors.

Chen X, Giraldes J, Sprague ER, Shakya S, Chen Z, Wang Y, Joud C, Mathieu S, Chen CH, Straub C, Duca J, Hurov K, Yuan Y, Shao W, Touré BB. Chen X, et al. Among authors: duca j. J Med Chem. 2017 Mar 9;60(5):2155-2161. doi: 10.1021/acs.jmedchem.7b00033. Epub 2017 Feb 24. J Med Chem. 2017. PMID: 28186750

3

Gazing into the crystal ball; the future of computer-aided drug design.

Martin E, Ertl P, Hunt P, Duca J, Lewis R. Martin E, et al. Among authors: duca j. J Comput Aided Mol Des. 2012 Jan;26(1):77-9. doi: 10.1007/s10822-011-9487-0. Epub 2011 Nov 17. J Comput Aided Mol Des. 2012. PMID: 22089332 No abstract available.

4

Uncoupling the Structure-Activity Relationships of β2 Adrenergic Receptor Ligands from Membrane Binding.

Dickson CJ, Hornak V, Velez-Vega C, McKay DJ, Reilly J, Sandham DA, Shaw D, Fairhurst RA, Charlton SJ, Sykes DA, Pearlstein RA, Duca JS. Dickson CJ, et al. Among authors: duca js. J Med Chem. 2016 Jun 23;59(12):5780-9. doi: 10.1021/acs.jmedchem.6b00358. Epub 2016 Jun 7. J Med Chem. 2016. PMID: 27239696

5

Building New Bridges between In Vitro and In Vivo in Early Drug Discovery: Where Molecular Modeling Meets Systems Biology.

Pearlstein RA, McKay DJJ, Hornak V, Dickson C, Golosov A, Harrison T, Velez-Vega C, Duca J. Pearlstein RA, et al. Among authors: duca j. Curr Top Med Chem. 2017;17(23):2642-2662. doi: 10.2174/1568026617666170414152311. Curr Top Med Chem. 2017. PMID: 28413952 Review.

6

Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hinge Binding Mode.

Huang X, Cheng CC, Fischmann TO, Duca JS, Yang X, Richards M, Shipps GW Jr. Huang X, et al. ACS Med Chem Lett. 2012 Jan 20;3(2):123-8. doi: 10.1021/ml200249h. eCollection 2012 Feb 9. ACS Med Chem Lett. 2012. PMID: 24900442 Free PMC article.

7

Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase.

Deng Y, Shipps GW Jr, Wang T, Popovici-Muller J, Rosner KE, Siddiqui MA, Duca J, Cooper AB, Cable M. Deng Y, et al. Among authors: duca j. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5363-7. doi: 10.1016/j.bmcl.2009.07.124. Epub 2009 Aug 6. Bioorg Med Chem Lett. 2009. PMID: 19682898

8

Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 2.

Labroli M, Paruch K, Dwyer MP, Alvarez C, Keertikar K, Poker C, Rossman R, Duca JS, Fischmann TO, Madison V, Parry D, Davis N, Seghezzi W, Wiswell D, Guzi TJ. Labroli M, et al. Among authors: duca js. Bioorg Med Chem Lett. 2011 Jan 1;21(1):471-4. doi: 10.1016/j.bmcl.2010.10.114. Epub 2010 Oct 28. Bioorg Med Chem Lett. 2011. PMID: 21094607

9

Structure-activity relationship (SAR) development and discovery of potent indole-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase.

Chen KX, Vibulbhan B, Yang W, Sannigrahi M, Velazquez F, Chan TY, Venkatraman S, Anilkumar GN, Zeng Q, Bennet F, Jiang Y, Lesburg CA, Duca J, Pinto P, Gavalas S, Huang Y, Wu W, Selyutin O, Agrawal S, Feld B, Huang HC, Li C, Cheng KC, Shih NY, Kozlowski JA, Rosenblum SB, Njoroge FG. Chen KX, et al. Among authors: duca j. J Med Chem. 2012 Jan 26;55(2):754-65. doi: 10.1021/jm201258k. Epub 2012 Jan 6. J Med Chem. 2012. PMID: 22148957

10

A novel class of highly potent irreversible hepatitis C virus NS5B polymerase inhibitors.

Chen KX, Lesburg CA, Vibulbhan B, Yang W, Chan TY, Venkatraman S, Velazquez F, Zeng Q, Bennett F, Anilkumar GN, Duca J, Jiang Y, Pinto P, Wang L, Huang Y, Selyutin O, Gavalas S, Pu H, Agrawal S, Feld B, Huang HC, Li C, Cheng KC, Shih NY, Kozlowski JA, Rosenblum SB, Njoroge FG. Chen KX, et al. Among authors: duca j. J Med Chem. 2012 Mar 8;55(5):2089-101. doi: 10.1021/jm201322r. Epub 2012 Feb 22. J Med Chem. 2012. PMID: 22247956

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