McIntyre A - Search Results

1

Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth.

McIntyre A, Hulikova A, Ledaki I, Snell C, Singleton D, Steers G, Seden P, Jones D, Bridges E, Wigfield S, Li JL, Russell A, Swietach P, Harris AL. McIntyre A, et al. Cancer Res. 2016 Jul 1;76(13):3744-55. doi: 10.1158/0008-5472.CAN-15-1862. Epub 2016 May 17. Cancer Res. 2016. PMID: 27197160

2

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

Dubois L, Peeters S, Lieuwes NG, Geusens N, Thiry A, Wigfield S, Carta F, McIntyre A, Scozzafava A, Dogné JM, Supuran CT, Harris AL, Masereel B, Lambin P. Dubois L, et al. Among authors: mcintyre a. Radiother Oncol. 2011 Jun;99(3):424-31. doi: 10.1016/j.radonc.2011.05.045. Epub 2011 Jun 14. Radiother Oncol. 2011. PMID: 21676479 Free article.

3

Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy.

McIntyre A, Patiar S, Wigfield S, Li JL, Ledaki I, Turley H, Leek R, Snell C, Gatter K, Sly WS, Vaughan-Jones RD, Swietach P, Harris AL. McIntyre A, et al. Clin Cancer Res. 2012 Jun 1;18(11):3100-11. doi: 10.1158/1078-0432.CCR-11-1877. Epub 2012 Apr 12. Clin Cancer Res. 2012. PMID: 22498007 Free PMC article.

4

Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells.

Favaro E, Bensaad K, Chong MG, Tennant DA, Ferguson DJ, Snell C, Steers G, Turley H, Li JL, Günther UL, Buffa FM, McIntyre A, Harris AL. Favaro E, et al. Among authors: mcintyre a. Cell Metab. 2012 Dec 5;16(6):751-64. doi: 10.1016/j.cmet.2012.10.017. Epub 2012 Nov 21. Cell Metab. 2012. PMID: 23177934 Free article.

5

Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours.

Snell CE, Turley H, McIntyre A, Li D, Masiero M, Schofield CJ, Gatter KC, Harris AL, Pezzella F. Snell CE, et al. Among authors: mcintyre a. PLoS One. 2014 Feb 12;9(2):e88955. doi: 10.1371/journal.pone.0088955. eCollection 2014. PLoS One. 2014. PMID: 24563687 Free PMC article.

6

Fatty acid-binding protein 4, a point of convergence for angiogenic and metabolic signaling pathways in endothelial cells.

Harjes U, Bridges E, McIntyre A, Fielding BA, Harris AL. Harjes U, et al. Among authors: mcintyre a. J Biol Chem. 2014 Aug 15;289(33):23168-23176. doi: 10.1074/jbc.M114.576512. Epub 2014 Jun 17. J Biol Chem. 2014. PMID: 24939870 Free PMC article.

7

Metabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentiality.

McIntyre A, Harris AL. McIntyre A, et al. EMBO Mol Med. 2015 Apr;7(4):368-79. doi: 10.15252/emmm.201404271. EMBO Mol Med. 2015. PMID: 25700172 Free PMC article. Review.

8

The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions.

Tapmeier TT, Moshnikova A, Beech J, Allen D, Kinchesh P, Smart S, Harris A, McIntyre A, Engelman DM, Andreev OA, Reshetnyak YK, Muschel RJ. Tapmeier TT, et al. Among authors: mcintyre a. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9710-5. doi: 10.1073/pnas.1509488112. Epub 2015 Jul 20. Proc Natl Acad Sci U S A. 2015. PMID: 26195776 Free PMC article.

9

Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors.

Gallagher FA, Sladen H, Kettunen MI, Serrao EM, Rodrigues TB, Wright A, Gill AB, McGuire S, Booth TC, Boren J, McIntyre A, Miller JL, Lee SH, Honess D, Day SE, Hu DE, Howat WJ, Harris AL, Brindle KM. Gallagher FA, et al. Among authors: mcintyre a. Cancer Res. 2015 Oct 1;75(19):4109-18. doi: 10.1158/0008-5472.CAN-15-0857. Epub 2015 Aug 6. Cancer Res. 2015. PMID: 26249175 Free PMC article.

10

Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition.

Ledaki I, McIntyre A, Wigfield S, Buffa F, McGowan S, Baban D, Li JL, Harris AL. Ledaki I, et al. Among authors: mcintyre a. Oncotarget. 2015 Aug 14;6(23):19413-27. doi: 10.18632/oncotarget.4989. Oncotarget. 2015. PMID: 26305601 Free PMC article.

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