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Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.
Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, MacLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Chen CX, Fon EA, Slack RS, Harper ME, McBride HM, Mak TW, Park DS. Irrcher I, et al. Among authors: harper me. Hum Mol Genet. 2010 Oct 1;19(19):3734-46. doi: 10.1093/hmg/ddq288. Epub 2010 Jul 16. Hum Mol Genet. 2010. PMID: 20639397
SPG7 variant escapes phosphorylation-regulated processing by AFG3L2, elevates mitochondrial ROS, and is associated with multiple clinical phenotypes.
Almontashiri NA, Chen HH, Mailloux RJ, Tatsuta T, Teng AC, Mahmoud AB, Ho T, Stewart NA, Rippstein P, Harper ME, Roberts R, Willenborg C, Erdmann J; CARDIoGRAM Consortium; Pastore A, McBride HM, Langer T, Stewart AF. Almontashiri NA, et al. Among authors: harper me. Cell Rep. 2014 May 8;7(3):834-47. doi: 10.1016/j.celrep.2014.03.051. Epub 2014 Apr 24. Cell Rep. 2014. PMID: 24767997 Free article.
OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.
Patten DA, Wong J, Khacho M, Soubannier V, Mailloux RJ, Pilon-Larose K, MacLaurin JG, Park DS, McBride HM, Trinkle-Mulcahy L, Harper ME, Germain M, Slack RS. Patten DA, et al. Among authors: harper me. EMBO J. 2014 Nov 18;33(22):2676-91. doi: 10.15252/embj.201488349. Epub 2014 Oct 8. EMBO J. 2014. PMID: 25298396 Free PMC article.
Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production.
Patten DA, McGuirk S, Anilkumar U, Antoun G, Gandhi K, Parmar G, Iqbal MA, Wong J, Richardson RB, St-Pierre J, Slack RS, Harper ME. Patten DA, et al. Among authors: harper me. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118854. doi: 10.1016/j.bbamcr.2020.118854. Epub 2020 Sep 11. Biochim Biophys Acta Mol Cell Res. 2021. PMID: 32926942 Free article.
310 results