Devkota A - Search Results

1

Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target.

Grandjean G, de Jong PR, James B, Koh MY, Lemos R, Kingston J, Aleshin A, Bankston LA, Miller CP, Cho EJ, Edupuganti R, Devkota A, Stancu G, Liddington RC, Dalby K, Powis G. Grandjean G, et al. Among authors: devkota a. Cancer Res. 2016 Jul 15;76(14):4259-4269. doi: 10.1158/0008-5472.CAN-16-0401. Epub 2016 Jun 3. Cancer Res. 2016. PMID: 27261507 Free PMC article.

2

Fluorescent peptide assays for protein kinases.

Devkota AK, Kaoud TS, Warthaka M, Dalby KN. Devkota AK, et al. Curr Protoc Mol Biol. 2010 Jul;Chapter 18:Unit 18.17. doi: 10.1002/0471142727.mb1817s91. Curr Protoc Mol Biol. 2010. PMID: 20583097 Free PMC article.

3

Activated ERK2 is a monomer in vitro with or without divalent cations and when complexed to the cytoplasmic scaffold PEA-15.

Kaoud TS, Devkota AK, Harris R, Rana MS, Abramczyk O, Warthaka M, Lee S, Girvin ME, Riggs AF, Dalby KN. Kaoud TS, et al. Biochemistry. 2011 May 31;50(21):4568-78. doi: 10.1021/bi200202y. Epub 2011 May 4. Biochemistry. 2011. PMID: 21506533 Free PMC article.

4

Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli.

Abramczyk O, Tavares CD, Devkota AK, Ryazanov AG, Turk BE, Riggs AF, Ozpolat B, Dalby KN. Abramczyk O, et al. Protein Expr Purif. 2011 Oct;79(2):237-44. doi: 10.1016/j.pep.2011.05.005. Epub 2011 May 14. Protein Expr Purif. 2011. PMID: 21605678 Free PMC article.

5

Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact.

Devkota AK, Tavares CD, Warthaka M, Abramczyk O, Marshall KD, Kaoud TS, Gorgulu K, Ozpolat B, Dalby KN. Devkota AK, et al. Biochemistry. 2012 Mar 13;51(10):2100-12. doi: 10.1021/bi201787p. Epub 2012 Mar 5. Biochemistry. 2012. PMID: 22352903 Free PMC article.

6

From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules.

Kaoud TS, Yan C, Mitra S, Tseng CC, Jose J, Taliaferro JM, Tuohetahuntila M, Devkota A, Sammons R, Park J, Park H, Shi Y, Hong J, Ren P, Dalby KN. Kaoud TS, et al. Among authors: devkota a. ACS Med Chem Lett. 2012 Aug 6;3(9):721-725. doi: 10.1021/ml300129b. ACS Med Chem Lett. 2012. PMID: 23002419 Free PMC article.

7

High-throughput screens for eEF-2 kinase.

Devkota AK, Warthaka M, Edupuganti R, Tavares CD, Johnson WH, Ozpolat B, Cho EJ, Dalby KN. Devkota AK, et al. J Biomol Screen. 2014 Mar;19(3):445-52. doi: 10.1177/1087057113505204. Epub 2013 Sep 27. J Biomol Screen. 2014. PMID: 24078616

8

Identification and validation of novel PERK inhibitors.

Wang Q, Park J, Devkota AK, Cho EJ, Dalby KN, Ren P. Wang Q, et al. J Chem Inf Model. 2014 May 27;54(5):1467-75. doi: 10.1021/ci500114r. Epub 2014 May 5. J Chem Inf Model. 2014. PMID: 24745945 Free PMC article.

9

Reversible covalent inhibition of eEF-2K by carbonitriles.

Devkota AK, Edupuganti R, Yan C, Shi Y, Jose J, Wang Q, Kaoud TS, Cho EJ, Ren P, Dalby KN. Devkota AK, et al. Chembiochem. 2014 Nov 3;15(16):2435-42. doi: 10.1002/cbic.201402321. Epub 2014 Sep 15. Chembiochem. 2014. PMID: 25224652 Free PMC article.

10

Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening.

Tavares CD, Devkota AK, Dalby KN, Cho EJ. Tavares CD, et al. Methods Mol Biol. 2016;1360:19-33. doi: 10.1007/978-1-4939-3073-9_2. Methods Mol Biol. 2016. PMID: 26501899

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