Koh MY - Search Results

1

Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target.

Grandjean G, de Jong PR, James B, Koh MY, Lemos R, Kingston J, Aleshin A, Bankston LA, Miller CP, Cho EJ, Edupuganti R, Devkota A, Stancu G, Liddington RC, Dalby K, Powis G. Grandjean G, et al. Among authors: koh my. Cancer Res. 2016 Jul 15;76(14):4259-4269. doi: 10.1158/0008-5472.CAN-16-0401. Epub 2016 Jun 3. Cancer Res. 2016. PMID: 27261507 Free PMC article.

2

The hypoxic inducible stress response as a target for cancer drug discovery.

Welsh SJ, Koh MY, Powis G. Welsh SJ, et al. Among authors: koh my. Semin Oncol. 2006 Aug;33(4):486-97. doi: 10.1053/j.seminoncol.2006.04.011. Semin Oncol. 2006. PMID: 16890803 Review.

3

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha.

Koh MY, Spivak-Kroizman T, Venturini S, Welsh S, Williams RR, Kirkpatrick DL, Powis G. Koh MY, et al. Mol Cancer Ther. 2008 Jan;7(1):90-100. doi: 10.1158/1535-7163.MCT-07-0463. Mol Cancer Ther. 2008. PMID: 18202012

4

Identification of thioredoxin-interacting protein 1 as a hypoxia-inducible factor 1alpha-induced gene in pancreatic cancer.

Baker AF, Koh MY, Williams RR, James B, Wang H, Tate WR, Gallegos A, Von Hoff DD, Han H, Powis G. Baker AF, et al. Among authors: koh my. Pancreas. 2008 Mar;36(2):178-86. doi: 10.1097/MPA.0b013e31815929fe. Pancreas. 2008. PMID: 18376310

5

Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.

Koh MY, Darnay BG, Powis G. Koh MY, et al. Mol Cell Biol. 2008 Dec;28(23):7081-95. doi: 10.1128/MCB.00773-08. Epub 2008 Oct 6. Mol Cell Biol. 2008. PMID: 18838541 Free PMC article.

6

HAF : the new player in oxygen-independent HIF-1alpha degradation.

Koh MY, Powis G. Koh MY, et al. Cell Cycle. 2009 May 1;8(9):1359-66. doi: 10.4161/cc.8.9.8303. Cell Cycle. 2009. PMID: 19377289 Free PMC article. Review.

7

Inhibiting the hypoxia response for cancer therapy: the new kid on the block.

Koh MY, Spivak-Kroizman TR, Powis G. Koh MY, et al. Clin Cancer Res. 2009 Oct 1;15(19):5945-6. doi: 10.1158/1078-0432.CCR-09-1650. Epub 2009 Sep 29. Clin Cancer Res. 2009. PMID: 19789327 Free PMC article.

8

HIF-1alpha and cancer therapy.

Koh MY, Spivak-Kroizman TR, Powis G. Koh MY, et al. Recent Results Cancer Res. 2010;180:15-34. doi: 10.1007/978-3-540-78281-0_3. Recent Results Cancer Res. 2010. PMID: 20033376 Review.

9

The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion.

Koh MY, Lemos R Jr, Liu X, Powis G. Koh MY, et al. Cancer Res. 2011 Jun 1;71(11):4015-27. doi: 10.1158/0008-5472.CAN-10-4142. Epub 2011 Apr 21. Cancer Res. 2011. PMID: 21512133 Free PMC article.

10

Passing the baton: the HIF switch.

Koh MY, Powis G. Koh MY, et al. Trends Biochem Sci. 2012 Sep;37(9):364-72. doi: 10.1016/j.tibs.2012.06.004. Epub 2012 Jul 18. Trends Biochem Sci. 2012. PMID: 22818162 Free PMC article. Review.

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