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Genetic variation at a single locus and age of onset for Alzheimer's disease.
Lutz MW, Crenshaw DG, Saunders AM, Roses AD. Lutz MW, et al. Among authors: roses ad. Alzheimers Dement. 2010 Mar;6(2):125-31. doi: 10.1016/j.jalz.2010.01.011. Alzheimers Dement. 2010. PMID: 20298972 Free PMC article.
The significant finding discussed here is that a variable-length, deoxythymidine homopolymer (poly-T) within intron 6 of the TOMM40 gene is associated with the age of onset of LOAD [Roses AD, Lutz MW, Amrine-Madsen H, Saunders AM, Crenshaw DG, Sundseth SS, et al. .. …
The significant finding discussed here is that a variable-length, deoxythymidine homopolymer (poly-T) within intron 6 of the TOMM40 gene is …
The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.
Linnertz C, Anderson L, Gottschalk W, Crenshaw D, Lutz MW, Allen J, Saith S, Mihovilovic M, Burke JR, Welsh-Bohmer KA, Roses AD, Chiba-Falek O. Linnertz C, et al. Among authors: roses ad. Alzheimers Dement. 2014 Sep;10(5):541-51. doi: 10.1016/j.jalz.2013.08.280. Epub 2014 Jan 15. Alzheimers Dement. 2014. PMID: 24439168 Free PMC article.
The Broad Impact of TOM40 on Neurodegenerative Diseases in Aging.
Gottschalk WK, Lutz MW, He YT, Saunders AM, Burns DK, Roses AD, Chiba-Falek O. Gottschalk WK, et al. Among authors: roses ad. J Parkinsons Dis Alzheimers Dis. 2014 Nov;1(1):12. doi: 10.13188/2376-922X.1000003. J Parkinsons Dis Alzheimers Dis. 2014. PMID: 25745640 Free PMC article.
Using genetics to enable studies on the prevention of Alzheimer's disease.
Crenshaw DG, Gottschalk WK, Lutz MW, Grossman I, Saunders AM, Burke JR, Welsh-Bohmer KA, Brannan SK, Burns DK, Roses AD. Crenshaw DG, et al. Among authors: roses ad. Clin Pharmacol Ther. 2013 Feb;93(2):177-85. doi: 10.1038/clpt.2012.222. Epub 2012 Nov 7. Clin Pharmacol Ther. 2013. PMID: 23249780 Free PMC article.
462 results