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Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment.
Blood. 2016 Sep 1;128(9):1193-205. doi: 10.1182/blood-2016-03-703702. Epub 2016 Jun 8.
Blood. 2016.
PMID: 27281795
Free PMC article.
Clinical Trial.
Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction.
Lim SP, Costantini B, Mian SA, Perez Abellan P, Gandhi S, Martinez Llordella M, Lozano JJ, Antunes Dos Reis R, Povoleri GAM, Mourikis TP, Abarrategi A, Ariza-McNaughton L, Heck S, Irish JM, Lombardi G, Marsh JCW, Bonnet D, Kordasti S, Mufti GJ.
Lim SP, et al. Among authors: perez abellan p.
Blood. 2020 Aug 13;136(7):885-897. doi: 10.1182/blood.2019001347.
Blood. 2020.
PMID: 32294156
Free PMC article.
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Mixed T Cell Chimerism After Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia Using an Alemtuzumab-Containing Regimen Is Shaped by Persistence of Recipient CD8 T Cells.
Grimaldi F, Potter V, Perez-Abellan P, Veluchamy JP, Atif M, Grain R, Sen M, Best S, Lea N, Rice C, Pagliuca A, Mufti GJ, Marsh JCW, Barber LD.
Grimaldi F, et al. Among authors: perez abellan p.
Biol Blood Marrow Transplant. 2017 Feb;23(2):293-299. doi: 10.1016/j.bbmt.2016.11.003. Epub 2016 Nov 2.
Biol Blood Marrow Transplant. 2017.
PMID: 27816648
Free PMC article.
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JAK inhibition induces silencing of T Helper cytokine secretion and a profound reduction in T regulatory cells.
Keohane C, Kordasti S, Seidl T, Perez Abellan P, Thomas NS, Harrison CN, McLornan DP, Mufti GJ.
Keohane C, et al. Among authors: perez abellan p.
Br J Haematol. 2015 Oct;171(1):60-73. doi: 10.1111/bjh.13519. Epub 2015 Jun 15.
Br J Haematol. 2015.
PMID: 26075866
Free article.
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Expansion of myeloid derived suppressor cells correlates with number of T regulatory cells and disease progression in myelodysplastic syndrome.
Kittang AO, Kordasti S, Sand KE, Costantini B, Kramer AM, Perezabellan P, Seidl T, Rye KP, Hagen KM, Kulasekararaj A, Bruserud Ø, Mufti GJ.
Kittang AO, et al.
Oncoimmunology. 2015 Jun 24;5(2):e1062208. doi: 10.1080/2162402X.2015.1062208. eCollection 2016 Feb.
Oncoimmunology. 2015.
PMID: 27057428
Free PMC article.
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