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The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.
da Motta LL, Ledaki I, Purshouse K, Haider S, De Bastiani MA, Baban D, Morotti M, Steers G, Wigfield S, Bridges E, Li JL, Knapp S, Ebner D, Klamt F, Harris AL, McIntyre A. da Motta LL, et al. Among authors: knapp s. Oncogene. 2017 Jan 5;36(1):122-132. doi: 10.1038/onc.2016.184. Epub 2016 Jun 13. Oncogene. 2017. PMID: 27292261 Free PMC article.
Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2.
Vogt M, Dudvarski Stankovic N, Cruz Garcia Y, Hofstetter J, Schneider K, Kuybu F, Hauck T, Adhikari B, Hamann A, Rocca Y, Grysczyk L, Martin B, Gebhardt-Wolf A, Wiegering A, Diefenbacher M, Gasteiger G, Knapp S, Saur D, Eilers M, Rosenfeldt M, Erhard F, Vos SM, Wolf E. Vogt M, et al. Among authors: knapp s. Gut. 2024 May 31:gutjnl-2023-331519. doi: 10.1136/gutjnl-2023-331519. Online ahead of print. Gut. 2024. PMID: 38821858 Free article.
Twenty years of big plant genera.
Moonlight PW, Baldaszti L, Cardoso D, Elliott A, Särkinen T, Knapp S. Moonlight PW, et al. Among authors: knapp s. Proc Biol Sci. 2024 May;291(2023):20240702. doi: 10.1098/rspb.2024.0702. Epub 2024 May 29. Proc Biol Sci. 2024. PMID: 38808446 Free article.
Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε.
de Souza Gama FH, Dutra LA, Hawgood M, Dos Reis CV, Serafim RAM, Ferreira MA Jr, Teodoro BVM, Takarada JE, Santiago AS, Balourdas DI, Nilsson AS, Urien B, Almeida VM, Gileadi C, Ramos PZ, Salmazo A, Vasconcelos SNS, Cunha MR, Mueller S, Knapp S, Massirer KB, Elkins JM, Gileadi O, Mascarello A, Lemmens BBLG, Guimarães CRW, Azevedo H, Couñago RM. de Souza Gama FH, et al. Among authors: knapp s. J Med Chem. 2024 May 23. doi: 10.1021/acs.jmedchem.3c02250. Online ahead of print. J Med Chem. 2024. PMID: 38780468
A chemical probe to modulate human GID4 Pro/N-degron interactions.
Owens DDG, Maitland MER, Khalili Yazdi A, Song X, Reber V, Schwalm MP, Machado RAC, Bauer N, Wang X, Szewczyk MM, Dong C, Dong A, Loppnau P, Calabrese MF, Dowling MS, Lee J, Montgomery JI, O'Connell TN, Subramanyam C, Wang F, Adamson EC, Schapira M, Gstaiger M, Knapp S, Vedadi M, Min J, Lajoie GA, Barsyte-Lovejoy D, Owen DR, Schild-Poulter C, Arrowsmith CH. Owens DDG, et al. Among authors: knapp s. Nat Chem Biol. 2024 May 21. doi: 10.1038/s41589-024-01618-0. Online ahead of print. Nat Chem Biol. 2024. PMID: 38773330
Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization.
Champiré A, Berabez R, Braka A, Cosson A, Corret J, Girardin C, Serrano A, Aci-Sèche S, Bonnet P, Josselin B, Brindeau P, Ruchaud S, Leguevel R, Chatterjee D, Mathea S, Knapp S, Brion R, Verrecchia F, Vallée B, Plé K, Bénédetti H, Routier S. Champiré A, et al. Among authors: knapp s. Eur J Med Chem. 2024 May 5;271:116391. doi: 10.1016/j.ejmech.2024.116391. Epub 2024 Apr 9. Eur J Med Chem. 2024. PMID: 38669909 Free article.
JAK-STAT signaling maintains homeostasis in T cells and macrophages.
Fortelny N, Farlik M, Fife V, Gorki AD, Lassnig C, Maurer B, Meissl K, Dolezal M, Boccuni L, Ravi Sundar Jose Geetha A, Akagha MJ, Karjalainen A, Shoebridge S, Farhat A, Mann U, Jain R, Tikoo S, Zila N, Esser-Skala W, Krausgruber T, Sitnik K, Penz T, Hladik A, Suske T, Zahalka S, Senekowitsch M, Barreca D, Halbritter F, Macho-Maschler S, Weninger W, Neubauer HA, Moriggl R, Knapp S, Sexl V, Strobl B, Decker T, Müller M, Bock C. Fortelny N, et al. Among authors: knapp s. Nat Immunol. 2024 May;25(5):847-859. doi: 10.1038/s41590-024-01804-1. Epub 2024 Apr 24. Nat Immunol. 2024. PMID: 38658806 Free PMC article.
1,284 results