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The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.
da Motta LL, Ledaki I, Purshouse K, Haider S, De Bastiani MA, Baban D, Morotti M, Steers G, Wigfield S, Bridges E, Li JL, Knapp S, Ebner D, Klamt F, Harris AL, McIntyre A. da Motta LL, et al. Among authors: purshouse k. Oncogene. 2017 Jan 5;36(1):122-132. doi: 10.1038/onc.2016.184. Epub 2016 Jun 13. Oncogene. 2017. PMID: 27292261 Free PMC article.
Challenges to DNA replication in hypoxic conditions.
Ng N, Purshouse K, Foskolou IP, Olcina MM, Hammond EM. Ng N, et al. Among authors: purshouse k. FEBS J. 2018 May;285(9):1563-1571. doi: 10.1111/febs.14377. Epub 2018 Jan 12. FEBS J. 2018. PMID: 29288533 Free article. Review.
Whole-genome sequencing identifies homozygous BRCA2 deletion guiding treatment in dedifferentiated prostate cancer.
Purshouse K, Schuh A, Fairfax BP, Knight S, Antoniou P, Dreau H, Popitsch N, Gatter K, Roberts I, Browning L, Traill Z, Kerr D, Verrill C, Tuthill M, Taylor JC, Protheroe A. Purshouse K, et al. Cold Spring Harb Mol Case Stud. 2017 May;3(3):a001362. doi: 10.1101/mcs.a001362. Cold Spring Harb Mol Case Stud. 2017. PMID: 28487881 Free PMC article.
Key findings from the UKCCMP cohort of 877 patients with haematological malignancy and COVID-19: disease control as an important factor relative to recent chemotherapy or anti-CD20 therapy.
Booth S, Curley HM, Varnai C, Arnold R, Lee LYW, Campton NA, Cook G, Purshouse K, Aries J, Innes A, Cook LB, Tomkins O, Oram HS, Tilby M, Kulasekararaj A, Wrench D, Dolly S, Newsom-Davies T, Pettengell R, Gault A, Moody S, Mittal S, Altohami M, Tillet T, Illingworth J, Mukherjee L, Apperly J, Ashcroft J, Rabin N, Carmichael J, Cazier JB, Kerr R, Middleton G, Collins GP, Palles C; UKCCMP team. Booth S, et al. Among authors: purshouse k. Br J Haematol. 2022 Feb;196(4):892-901. doi: 10.1111/bjh.17937. Epub 2021 Nov 10. Br J Haematol. 2022. PMID: 34761389 Free PMC article.
Distinguishing between direct and indirect consequences of covid-19.
Figueroa JD, Brennan PM, Theodoratou E, Poon MTC, Purshouse K, Din FVN, Jin K, Mesa-Eguiagaray I, Dunlop MG, Hall PS, Cameron D, Wild SH, Sudlow CLM. Figueroa JD, et al. Among authors: purshouse k. BMJ. 2020 Jun 15;369:m2377. doi: 10.1136/bmj.m2377. BMJ. 2020. PMID: 32540857 No abstract available.
26 results