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Neddylation requires glycyl-tRNA synthetase to protect activated E2.
Mo Z, Zhang Q, Liu Z, Lauer J, Shi Y, Sun L, Griffin PR, Yang XL. Mo Z, et al. Among authors: sun l. Nat Struct Mol Biol. 2016 Aug;23(8):730-7. doi: 10.1038/nsmb.3250. Epub 2016 Jun 27. Nat Struct Mol Biol. 2016. PMID: 27348078 Free PMC article.
Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases.
Niehues S, Bussmann J, Steffes G, Erdmann I, Köhrer C, Sun L, Wagner M, Schäfer K, Wang G, Koerdt SN, Stum M, Jaiswal S, RajBhandary UL, Thomas U, Aberle H, Burgess RW, Yang XL, Dieterich D, Storkebaum E. Niehues S, et al. Among authors: sun l. Nat Commun. 2015 Jul 3;6:7520. doi: 10.1038/ncomms8520. Nat Commun. 2015. PMID: 26138142 Free PMC article.
CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS.
Sun L, Wei N, Kuhle B, Blocquel D, Novick S, Matuszek Z, Zhou H, He W, Zhang J, Weber T, Horvath R, Latour P, Pan T, Schimmel P, Griffin PR, Yang XL. Sun L, et al. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2012898118. doi: 10.1073/pnas.2012898118. Proc Natl Acad Sci U S A. 2021. PMID: 33753480 Free PMC article.
CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells.
Blocquel D, Sun L, Matuszek Z, Li S, Weber T, Kuhle B, Kooi G, Wei N, Baets J, Pan T, Schimmel P, Yang XL. Blocquel D, et al. Among authors: sun l. Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19440-19448. doi: 10.1073/pnas.1908288116. Epub 2019 Sep 9. Proc Natl Acad Sci U S A. 2019. PMID: 31501329 Free PMC article.
ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase.
Vo MN, Terrey M, Lee JW, Roy B, Moresco JJ, Sun L, Fu H, Liu Q, Weber TG, Yates JR 3rd, Fredrick K, Schimmel P, Ackerman SL. Vo MN, et al. Among authors: sun l. Nature. 2018 May;557(7706):510-515. doi: 10.1038/s41586-018-0137-8. Epub 2018 May 16. Nature. 2018. PMID: 29769718 Free PMC article.
Corrigendum: Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases.
Niehues S, Bussmann J, Steffes G, Erdmann I, Köhrer C, Sun L, Wagner M, Schäfer K, Wang G, Koerdt SN, Stum M, Jaiswal S, RajBhandary UL, Thomas U, Aberle H, Burgess RW, Yang XL, Dieterich D, Storkebaum E. Niehues S, et al. Among authors: sun l. Nat Commun. 2016 Jan 21;7:10497. doi: 10.1038/ncomms10497. Nat Commun. 2016. PMID: 26792285 Free PMC article. No abstract available.
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