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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Chen YN, LaMarche MJ, Chan HM, Fekkes P, Garcia-Fortanet J, Acker MG, Antonakos B, Chen CH, Chen Z, Cooke VG, Dobson JR, Deng Z, Fei F, Firestone B, Fodor M, Fridrich C, Gao H, Grunenfelder D, Hao HX, Jacob J, Ho S, Hsiao K, Kang ZB, Karki R, Kato M, Larrow J, La Bonte LR, Lenoir F, Liu G, Liu S, Majumdar D, Meyer MJ, Palermo M, Perez L, Pu M, Price E, Quinn C, Shakya S, Shultz MD, Slisz J, Venkatesan K, Wang P, Warmuth M, Williams S, Yang G, Yuan J, Zhang JH, Zhu P, Ramsey T, Keen NJ, Sellers WR, Stams T, Fortin PD. Chen YN, et al. Among authors: chen z, chen ch. Nature. 2016 Jul 7;535(7610):148-52. doi: 10.1038/nature18621. Epub 2016 Jun 29. Nature. 2016. PMID: 27362227
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.
Garcia Fortanet J, Chen CH, Chen YN, Chen Z, Deng Z, Firestone B, Fekkes P, Fodor M, Fortin PD, Fridrich C, Grunenfelder D, Ho S, Kang ZB, Karki R, Kato M, Keen N, LaBonte LR, Larrow J, Lenoir F, Liu G, Liu S, Lombardo F, Majumdar D, Meyer MJ, Palermo M, Perez L, Pu M, Ramsey T, Sellers WR, Shultz MD, Stams T, Towler C, Wang P, Williams SL, Zhang JH, LaMarche MJ. Garcia Fortanet J, et al. Among authors: chen z, chen ch, chen yn. J Med Chem. 2016 Sep 8;59(17):7773-82. doi: 10.1021/acs.jmedchem.6b00680. Epub 2016 Jul 12. J Med Chem. 2016. PMID: 27347692
Validating cancer drug targets.
Benson JD, Chen YN, Cornell-Kennon SA, Dorsch M, Kim S, Leszczyniecka M, Sellers WR, Lengauer C. Benson JD, et al. Among authors: chen yn. Nature. 2006 May 25;441(7092):451-6. doi: 10.1038/nature04873. Nature. 2006. PMID: 16724057 Review.
Preconfigured architecture of the developing mouse brain.
Chini M, Hnida M, Kostka JK, Chen YN, Hanganu-Opatz IL. Chini M, et al. Among authors: chen yn. Cell Rep. 2024 May 24;43(6):114267. doi: 10.1016/j.celrep.2024.114267. Online ahead of print. Cell Rep. 2024. PMID: 38795344 Free article.
Bleeding Risk of Cold Versus Hot Snare Polypectomy for Pedunculated Colorectal Polyps Measuring 10 mm or Less: Subgroup Analysis of a Large Randomized Controlled Trial.
Tseng CH, Chang LC, Wu JL, Chang CY, Chen CY, Chen PJ, Shun CT, Hsu WF, Chen YN, Chen CC, Huang TY, Tu CH, Chen MJ, Chou CK, Lee CT, Chen PY, Lin JT, Wu MS, Chiu HM. Tseng CH, et al. Among authors: chen yn. Am J Gastroenterol. 2024 May 23. doi: 10.14309/ajg.0000000000002847. Online ahead of print. Am J Gastroenterol. 2024. PMID: 38775310
[Clinical diagnostic practices for Chinese developmental dyslexia].
Liu ZL, Huo YY, Chen YN, Chi X, Zhang YY, Dong CF, Wu D, Liu SY, Zhu J, Chen JJ. Liu ZL, et al. Among authors: chen yn. Zhonghua Er Ke Za Zhi. 2024 May 15;62(6):548-552. doi: 10.3760/cma.j.cn112140-20240221-00114. Online ahead of print. Zhonghua Er Ke Za Zhi. 2024. PMID: 38763877 Chinese.
Contemporary Management of Pediatric Brainstem Tumors.
Chou SC, Chen YN, Huang HY, Kuo MF, Wong TT, Kuo SH, Yang SH. Chou SC, et al. Among authors: chen yn. Adv Tech Stand Neurosurg. 2024;49:231-254. doi: 10.1007/978-3-031-42398-7_11. Adv Tech Stand Neurosurg. 2024. PMID: 38700687 Review.
612 results