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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Nature. 2016 Jul 7;535(7610):148-52. doi: 10.1038/nature18621. Epub 2016 Jun 29.
Nature. 2016.
PMID: 27362227
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.
Garcia Fortanet J, Chen CH, Chen YN, Chen Z, Deng Z, Firestone B, Fekkes P, Fodor M, Fortin PD, Fridrich C, Grunenfelder D, Ho S, Kang ZB, Karki R, Kato M, Keen N, LaBonte LR, Larrow J, Lenoir F, Liu G, Liu S, Lombardo F, Majumdar D, Meyer MJ, Palermo M, Perez L, Pu M, Ramsey T, Sellers WR, Shultz MD, Stams T, Towler C, Wang P, Williams SL, Zhang JH, LaMarche MJ.
Garcia Fortanet J, et al. Among authors: grunenfelder d.
J Med Chem. 2016 Sep 8;59(17):7773-82. doi: 10.1021/acs.jmedchem.6b00680. Epub 2016 Jul 12.
J Med Chem. 2016.
PMID: 27347692
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Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.
LaMarche MJ, Acker M, Argintaru A, Bauer D, Boisclair J, Chan H, Chen CH, Chen YN, Chen Z, Deng Z, Dore M, Dunstan D, Fan J, Fekkes P, Firestone B, Fodor M, Garcia-Fortanet J, Fortin PD, Fridrich C, Giraldes J, Glick M, Grunenfelder D, Hao HX, Hentemann M, Ho S, Jouk A, Kang ZB, Karki R, Kato M, Keen N, Koenig R, LaBonte LR, Larrow J, Liu G, Liu S, Majumdar D, Mathieu S, Meyer MJ, Mohseni M, Ntaganda R, Palermo M, Perez L, Pu M, Ramsey T, Reilly J, Sarver P, Sellers WR, Sendzik M, Shultz MD, Slisz J, Slocum K, Smith T, Spence S, Stams T, Straub C, Tamez V Jr, Toure BB, Towler C, Wang P, Wang H, Williams SL, Yang F, Yu B, Zhang JH, Zhu S.
LaMarche MJ, et al. Among authors: grunenfelder d.
J Med Chem. 2020 Nov 25;63(22):13578-13594. doi: 10.1021/acs.jmedchem.0c01170. Epub 2020 Sep 24.
J Med Chem. 2020.
PMID: 32910655
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Radical Deoxychlorination of Cesium Oxalates for the Synthesis of Alkyl Chlorides.
Su JY, Grünenfelder DC, Takeuchi K, Reisman SE.
Su JY, et al. Among authors: grunenfelder dc.
Org Lett. 2018 Aug 17;20(16):4912-4916. doi: 10.1021/acs.orglett.8b02045. Epub 2018 Jul 31.
Org Lett. 2018.
PMID: 30062894
Free article.
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Enantioselective Synthesis of (-)-10-Hydroxyacutuminine.
Grünenfelder DC, Navarro R, Wang H, Fastuca NJ, Butler JR, Reisman SE.
Grünenfelder DC, et al.
Angew Chem Int Ed Engl. 2022 Apr 11;61(16):e202117480. doi: 10.1002/anie.202117480. Epub 2022 Feb 23.
Angew Chem Int Ed Engl. 2022.
PMID: 35112449
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