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Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model.
Cook C, Kang SS, Carlomagno Y, Lin WL, Yue M, Kurti A, Shinohara M, Jansen-West K, Perkerson E, Castanedes-Casey M, Rousseau L, Phillips V, Bu G, Dickson DW, Petrucelli L, Fryer JD. Cook C, et al. Among authors: kang ss. Hum Mol Genet. 2015 Nov 1;24(21):6198-212. doi: 10.1093/hmg/ddv336. Epub 2015 Aug 13. Hum Mol Genet. 2015. PMID: 26276810 Free PMC article.
Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways.
Wojtas AM, Kang SS, Olley BM, Gatherer M, Shinohara M, Lozano PA, Liu CC, Kurti A, Baker KE, Dickson DW, Yue M, Petrucelli L, Bu G, Carare RO, Fryer JD. Wojtas AM, et al. Among authors: kang ss. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6962-E6971. doi: 10.1073/pnas.1701137114. Epub 2017 Jul 12. Proc Natl Acad Sci U S A. 2017. PMID: 28701379 Free PMC article.
Astrocyte-derived clusterin suppresses amyloid formation in vivo.
Wojtas AM, Sens JP, Kang SS, Baker KE, Berry TJ, Kurti A, Daughrity L, Jansen-West KR, Dickson DW, Petrucelli L, Bu G, Liu CC, Fryer JD. Wojtas AM, et al. Among authors: kang ss. Mol Neurodegener. 2020 Nov 27;15(1):71. doi: 10.1186/s13024-020-00416-1. Mol Neurodegener. 2020. PMID: 33246484 Free PMC article.
Lipocalin-2 protects the brain during inflammatory conditions.
Kang SS, Ren Y, Liu CC, Kurti A, Baker KE, Bu G, Asmann Y, Fryer JD. Kang SS, et al. Mol Psychiatry. 2018 Feb;23(2):344-350. doi: 10.1038/mp.2016.243. Epub 2017 Jan 10. Mol Psychiatry. 2018. PMID: 28070126 Free PMC article.
Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.
Zheng H, Liu CC, Atagi Y, Chen XF, Jia L, Yang L, He W, Zhang X, Kang SS, Rosenberry TL, Fryer JD, Zhang YW, Xu H, Bu G. Zheng H, et al. Among authors: kang ss. Neurobiol Aging. 2016 Jun;42:132-41. doi: 10.1016/j.neurobiolaging.2016.03.004. Epub 2016 Mar 16. Neurobiol Aging. 2016. PMID: 27143430 Free PMC article.
Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation.
Wojtas AM, Carlomagno Y, Sens JP, Kang SS, Jensen TD, Kurti A, Baker KE, Berry TJ, Phillips VR, Castanedes MC, Awan A, DeTure M, De Castro CHF, Librero AL, Yue M, Daughrity L, Jansen-West KR, Cook CN, Dickson DW, Petrucelli L, Fryer JD. Wojtas AM, et al. Among authors: kang ss. Acta Neuropathol Commun. 2020 Dec 1;8(1):210. doi: 10.1186/s40478-020-01079-1. Acta Neuropathol Commun. 2020. PMID: 33261653 Free PMC article.
1,233 results