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Structural Determinants of Sleeping Beauty Transposase Activity.
Abrusán G, Yant SR, Szilágyi A, Marsh JA, Mátés L, Izsvák Z, Barabás O, Ivics Z. Abrusán G, et al. Among authors: barabas o. Mol Ther. 2016 Aug;24(8):1369-77. doi: 10.1038/mt.2016.110. Epub 2016 Jun 6. Mol Ther. 2016. PMID: 27401040 Free PMC article.
A single amino acid switch converts the Sleeping Beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming.
Kesselring L, Miskey C, Zuliani C, Querques I, Kapitonov V, Laukó A, Fehér A, Palazzo A, Diem T, Lustig J, Sebe A, Wang Y, Dinnyés A, Izsvák Z, Barabas O, Ivics Z. Kesselring L, et al. Among authors: barabas o. Nucleic Acids Res. 2020 Jan 10;48(1):316-331. doi: 10.1093/nar/gkz1119. Nucleic Acids Res. 2020. PMID: 31777924 Free PMC article.
A highly soluble Sleeping Beauty transposase improves control of gene insertion.
Querques I, Mades A, Zuliani C, Miskey C, Alb M, Grueso E, Machwirth M, Rausch T, Einsele H, Ivics Z, Hudecek M, Barabas O. Querques I, et al. Among authors: barabas o. Nat Biotechnol. 2019 Dec;37(12):1502-1512. doi: 10.1038/s41587-019-0291-z. Epub 2019 Nov 4. Nat Biotechnol. 2019. PMID: 31685959 Free PMC article.
Jump ahead with a twist: DNA acrobatics drive transposition forward.
Arinkin V, Smyshlyaev G, Barabas O. Arinkin V, et al. Among authors: barabas o. Curr Opin Struct Biol. 2019 Dec;59:168-177. doi: 10.1016/j.sbi.2019.08.006. Epub 2019 Oct 5. Curr Opin Struct Biol. 2019. PMID: 31590109 Free PMC article. Review.
40 results