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An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.
Biochem J. 2016 Oct 1;473(19):3269-90. doi: 10.1042/BCJ20160159. Epub 2016 Jul 12.
Biochem J. 2016.
PMID: 27407165
Free PMC article.
An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein.
Irving JA, Miranda E, Haq I, Perez J, Kotov VR, Faull SV, Motamedi-Shad N, Lomas DA.
Irving JA, et al. Among authors: motamedi shad n.
Biochem J. 2015 May 15;468(1):99-108. doi: 10.1042/BJ20141569.
Biochem J. 2015.
PMID: 25738741
Free PMC article.
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A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity.
Ordóñez A, Pérez J, Tan L, Dickens JA, Motamedi-Shad N, Irving JA, Haq I, Ekeowa U, Marciniak SJ, Miranda E, Lomas DA.
Ordóñez A, et al. Among authors: motamedi shad n.
FASEB J. 2015 Jun;29(6):2667-78. doi: 10.1096/fj.14-267351. Epub 2015 Mar 10.
FASEB J. 2015.
PMID: 25757566
Free PMC article.
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Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization.
Haq I, Irving JA, Saleh AD, Dron L, Regan-Mochrie GL, Motamedi-Shad N, Hurst JR, Gooptu B, Lomas DA.
Haq I, et al. Among authors: motamedi shad n.
Am J Respir Cell Mol Biol. 2016 Jan;54(1):71-80. doi: 10.1165/rcmb.2015-0154OC.
Am J Respir Cell Mol Biol. 2016.
PMID: 26091018
Free PMC article.
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Rapid oligomer formation of human muscle acylphosphatase induced by heparan sulfate.
Motamedi-Shad N, Garfagnini T, Penco A, Relini A, Fogolari F, Corazza A, Esposito G, Bemporad F, Chiti F.
Motamedi-Shad N, et al.
Nat Struct Mol Biol. 2012 Apr 22;19(5):547-54, S1-2. doi: 10.1038/nsmb.2286.
Nat Struct Mol Biol. 2012.
PMID: 22522822
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Amyloid formation by the model protein muscle acylphosphatase is accelerated by heparin and heparan sulphate through a scaffolding-based mechanism.
Motamedi-Shad N, Monsellier E, Chiti F.
Motamedi-Shad N, et al.
J Biochem. 2009 Dec;146(6):805-14. doi: 10.1093/jb/mvp128. Epub 2009 Aug 12.
J Biochem. 2009.
PMID: 19675100
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Kinetic analysis of amyloid formation in the presence of heparan sulfate: faster unfolding and change of pathway.
Motamedi-Shad N, Monsellier E, Torrassa S, Relini A, Chiti F.
Motamedi-Shad N, et al.
J Biol Chem. 2009 Oct 23;284(43):29921-34. doi: 10.1074/jbc.M109.018747. Epub 2009 Aug 21.
J Biol Chem. 2009.
PMID: 19700762
Free PMC article.
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