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CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis.
Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P, Maegdefessel L, Matic LP, Hedin U, Weissman IL, Leeper NJ. Kojima Y, et al. Among authors: hedin u. Nature. 2016 Aug 4;536(7614):86-90. doi: 10.1038/nature18935. Epub 2016 Jul 20. Nature. 2016. PMID: 27437576 Free PMC article.
Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis.
Kojima Y, Downing K, Kundu R, Miller C, Dewey F, Lancero H, Raaz U, Perisic L, Hedin U, Schadt E, Maegdefessel L, Quertermous T, Leeper NJ. Kojima Y, et al. Among authors: hedin u. J Clin Invest. 2014 Mar;124(3):1083-97. doi: 10.1172/JCI70391. Epub 2014 Feb 17. J Clin Invest. 2014. PMID: 24531546 Free PMC article.
Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.
Miller CL, Haas U, Diaz R, Leeper NJ, Kundu RK, Patlolla B, Assimes TL, Kaiser FJ, Perisic L, Hedin U, Maegdefessel L, Schunkert H, Erdmann J, Quertermous T, Sczakiel G. Miller CL, et al. Among authors: hedin u. PLoS Genet. 2014 Mar 27;10(3):e1004263. doi: 10.1371/journal.pgen.1004263. eCollection 2014 Mar. PLoS Genet. 2014. PMID: 24676100 Free PMC article.
Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap.
Nurnberg ST, Cheng K, Raiesdana A, Kundu R, Miller CL, Kim JB, Arora K, Carcamo-Oribe I, Xiong Y, Tellakula N, Nanda V, Murthy N, Boisvert WA, Hedin U, Perisic L, Aldi S, Maegdefessel L, Pjanic M, Owens GK, Tallquist MD, Quertermous T. Nurnberg ST, et al. Among authors: hedin u. PLoS Genet. 2015 May 28;11(5):e1005155. doi: 10.1371/journal.pgen.1005155. eCollection 2015 May. PLoS Genet. 2015. PMID: 26020946 Free PMC article.
CDKN2B Regulates TGFβ Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels.
Nanda V, Downing KP, Ye J, Xiao S, Kojima Y, Spin JM, DiRenzo D, Nead KT, Connolly AJ, Dandona S, Perisic L, Hedin U, Maegdefessel L, Dalman J, Guo L, Zhao X, Kolodgie FD, Virmani R, Davis HR Jr, Leeper NJ. Nanda V, et al. Among authors: hedin u. Circ Res. 2016 Jan 22;118(2):230-40. doi: 10.1161/CIRCRESAHA.115.307906. Epub 2015 Nov 23. Circ Res. 2016. PMID: 26596284 Free PMC article.
Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci.
Miller CL, Pjanic M, Wang T, Nguyen T, Cohain A, Lee JD, Perisic L, Hedin U, Kundu RK, Majmudar D, Kim JB, Wang O, Betsholtz C, Ruusalepp A, Franzén O, Assimes TL, Montgomery SB, Schadt EE, Björkegren JLM, Quertermous T. Miller CL, et al. Among authors: hedin u. Nat Commun. 2016 Jul 8;7:12092. doi: 10.1038/ncomms12092. Nat Commun. 2016. PMID: 27386823 Free PMC article.
Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.
Perisic Matic L, Rykaczewska U, Razuvaev A, Sabater-Lleal M, Lengquist M, Miller CL, Ericsson I, Röhl S, Kronqvist M, Aldi S, Magné J, Paloschi V, Vesterlund M, Li Y, Jin H, Diez MG, Roy J, Baldassarre D, Veglia F, Humphries SE, de Faire U, Tremoli E, Odeberg J, Vukojević V, Lehtiö J, Maegdefessel L, Ehrenborg E, Paulsson-Berne G, Hansson GK, Lindeman JH, Eriksson P, Quertermous T, Hamsten A, Hedin U. Perisic Matic L, et al. Among authors: hedin u. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1947-61. doi: 10.1161/ATVBAHA.116.307893. Epub 2016 Jul 28. Arterioscler Thromb Vasc Biol. 2016. PMID: 27470516 Free PMC article.
Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis.
Karunakaran D, Geoffrion M, Wei L, Gan W, Richards L, Shangari P, DeKemp EM, Beanlands RA, Perisic L, Maegdefessel L, Hedin U, Sad S, Guo L, Kolodgie FD, Virmani R, Ruddy T, Rayner KJ. Karunakaran D, et al. Among authors: hedin u. Sci Adv. 2016 Jul 22;2(7):e1600224. doi: 10.1126/sciadv.1600224. eCollection 2016 Jul. Sci Adv. 2016. PMID: 27532042 Free PMC article.
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Lunella FF, Jaé N, Rossbach O, Amrhein C, Sigala F, Boon RA, Fürtig B, Manavski Y, You X, Uchida S, Keller T, Boeckel JN, Franco-Cereceda A, Maegdefessel L, Chen W, Schwalbe H, Bindereif A, Eriksson P, Hedin U, Zeiher AM, Dimmeler S. Stellos K, et al. Among authors: hedin u. Nat Med. 2016 Oct;22(10):1140-1150. doi: 10.1038/nm.4172. Epub 2016 Sep 5. Nat Med. 2016. PMID: 27595325
MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions.
Eken SM, Jin H, Chernogubova E, Li Y, Simon N, Sun C, Korzunowicz G, Busch A, Bäcklund A, Österholm C, Razuvaev A, Renné T, Eckstein HH, Pelisek J, Eriksson P, González Díez M, Perisic Matic L, Schellinger IN, Raaz U, Leeper NJ, Hansson GK, Paulsson-Berne G, Hedin U, Maegdefessel L. Eken SM, et al. Among authors: hedin u. Circ Res. 2017 Feb 17;120(4):633-644. doi: 10.1161/CIRCRESAHA.116.309318. Epub 2016 Nov 28. Circ Res. 2017. PMID: 27895035
240 results