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Hhip haploinsufficiency sensitizes mice to age-related emphysema.
Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang C, Mancini JD, Gupta K, Laucho-Contreras ME, Naing ZZ, Zhang L, Perrella MA, Owen CA, Silverman EK, Zhou X. Lao T, et al. Among authors: zhou x. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4681-7. doi: 10.1073/pnas.1602342113. Epub 2016 Jul 21. Proc Natl Acad Sci U S A. 2016. PMID: 27444019 Free PMC article.
Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP.
Zhou X, Baron RM, Hardin M, Cho MH, Zielinski J, Hawrylkiewicz I, Sliwinski P, Hersh CP, Mancini JD, Lu K, Thibault D, Donahue AL, Klanderman BJ, Rosner B, Raby BA, Lu Q, Geldart AM, Layne MD, Perrella MA, Weiss ST, Choi AM, Silverman EK. Zhou X, et al. Hum Mol Genet. 2012 Mar 15;21(6):1325-35. doi: 10.1093/hmg/ddr569. Epub 2011 Dec 2. Hum Mol Genet. 2012. PMID: 22140090 Free PMC article.
Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells.
Zhou X, Qiu W, Sathirapongsasuti JF, Cho MH, Mancini JD, Lao T, Thibault DM, Litonjua AA, Bakke PS, Gulsvik A, Lomas DA, Beaty TH, Hersh CP, Anderson C, Geigenmuller U, Raby BA, Rennard SI, Perrella MA, Choi AM, Quackenbush J, Silverman EK. Zhou X, et al. Genomics. 2013 May;101(5):263-72. doi: 10.1016/j.ygeno.2013.02.010. Epub 2013 Mar 1. Genomics. 2013. PMID: 23459001 Free PMC article.
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.
Cho MH, McDonald ML, Zhou X, Mattheisen M, Castaldi PJ, Hersh CP, Demeo DL, Sylvia JS, Ziniti J, Laird NM, Lange C, Litonjua AA, Sparrow D, Casaburi R, Barr RG, Regan EA, Make BJ, Hokanson JE, Lutz S, Dudenkov TM, Farzadegan H, Hetmanski JB, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH; NETT Genetics, ICGN, ECLIPSE and COPDGene Investigators. Cho MH, et al. Among authors: zhou x. Lancet Respir Med. 2014 Mar;2(3):214-25. doi: 10.1016/S2213-2600(14)70002-5. Epub 2014 Feb 7. Lancet Respir Med. 2014. PMID: 24621683 Free PMC article.
Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci.
Castaldi PJ, Cho MH, Zhou X, Qiu W, Mcgeachie M, Celli B, Bakke P, Gulsvik A, Lomas DA, Crapo JD, Beaty TH, Rennard S, Harshfield B, Lange C, Singh D, Tal-Singer R, Riley JH, Quackenbush J, Raby BA, Carey VJ, Silverman EK, Hersh CP. Castaldi PJ, et al. Among authors: zhou x. Hum Mol Genet. 2015 Feb 15;24(4):1200-10. doi: 10.1093/hmg/ddu525. Epub 2014 Oct 14. Hum Mol Genet. 2015. PMID: 25315895 Free PMC article.
A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma.
Sharma A, Menche J, Huang CC, Ort T, Zhou X, Kitsak M, Sahni N, Thibault D, Voung L, Guo F, Ghiassian SD, Gulbahce N, Baribaud F, Tocker J, Dobrin R, Barnathan E, Liu H, Panettieri RA Jr, Tantisira KG, Qiu W, Raby BA, Silverman EK, Vidal M, Weiss ST, Barabási AL. Sharma A, et al. Among authors: zhou x. Hum Mol Genet. 2015 Jun 1;24(11):3005-20. doi: 10.1093/hmg/ddv001. Epub 2015 Jan 12. Hum Mol Genet. 2015. PMID: 25586491 Free PMC article.
Impaired E Prostanoid2 Expression and Resistance to Prostaglandin E2 in Nasal Polyp Fibroblasts from Subjects with Aspirin-Exacerbated Respiratory Disease.
Cahill KN, Raby BA, Zhou X, Guo F, Thibault D, Baccarelli A, Byun HM, Bhattacharyya N, Steinke JW, Boyce JA, Laidlaw TM. Cahill KN, et al. Among authors: zhou x. Am J Respir Cell Mol Biol. 2016 Jan;54(1):34-40. doi: 10.1165/rcmb.2014-0486OC. Am J Respir Cell Mol Biol. 2016. PMID: 26051534 Free PMC article.
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