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Artificial intelligence for dementia drug discovery and trials optimization.
Doherty T, Yao Z, Khleifat AAL, Tantiangco H, Tamburin S, Albertyn C, Thakur L, Llewellyn DJ, Oxtoby NP, Lourida I; Deep Dementia Phenotyping (DEMON) Network; Ranson JM, Duce JA. Doherty T, et al. Among authors: duce ja. Alzheimers Dement. 2023 Dec;19(12):5922-5933. doi: 10.1002/alz.13428. Epub 2023 Aug 16. Alzheimers Dement. 2023. PMID: 37587767 Free article. Review.
Trial of Deferiprone in Parkinson's Disease.
Devos D, Labreuche J, Rascol O, Corvol JC, Duhamel A, Guyon Delannoy P, Poewe W, Compta Y, Pavese N, Růžička E, Dušek P, Post B, Bloem BR, Berg D, Maetzler W, Otto M, Habert MO, Lehericy S, Ferreira J, Dodel R, Tranchant C, Eusebio A, Thobois S, Marques AR, Meissner WG, Ory-Magne F, Walter U, de Bie RMA, Gago M, Vilas D, Kulisevsky J, Januario C, Coelho MVS, Behnke S, Worth P, Seppi K, Ouk T, Potey C, Leclercq C, Viard R, Kuchcinski G, Lopes R, Pruvo JP, Pigny P, Garçon G, Simonin O, Carpentier J, Rolland AS, Nyholm D, Scherfler C, Mangin JF, Chupin M, Bordet R, Dexter DT, Fradette C, Spino M, Tricta F, Ayton S, Bush AI, Devedjian JC, Duce JA, Cabantchik I, Defebvre L, Deplanque D, Moreau C; FAIRPARK-II Study Group. Devos D, et al. Among authors: duce ja. N Engl J Med. 2022 Dec 1;387(22):2045-2055. doi: 10.1056/NEJMoa2209254. N Engl J Med. 2022. PMID: 36449420 Clinical Trial.
Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function.
Carling PJ, Ryan BJ, McGuinness W, Kataria S, Humble SW, Milde S, Duce JA, Kapadia N, Zuercher WJ, Davis JB, Di Daniel E, Wade-Martins R. Carling PJ, et al. Among authors: duce ja. Autophagy. 2023 Feb;19(2):692-705. doi: 10.1080/15548627.2022.2095834. Epub 2022 Jul 25. Autophagy. 2023. PMID: 35786165 Free PMC article.
Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
Boffey HK, Rooney TPC, Willems HMG, Edwards S, Green C, Howard T, Ogg D, Romero T, Scott DE, Winpenny D, Duce J, Skidmore J, Clarke JH, Andrews SP. Boffey HK, et al. Among authors: duce j. J Med Chem. 2022 Feb 24;65(4):3359-3370. doi: 10.1021/acs.jmedchem.1c01819. Epub 2022 Feb 11. J Med Chem. 2022. PMID: 35148092 Free PMC article.
Synthesis, physicochemical characterization and neuroprotective evaluation of novel 1-hydroxypyrazin-2(1H)-one iron chelators in an in vitro cell model of Parkinson's disease.
Lewis FW, Bird K, Navarro JP, El Fallah R, Brandel J, Hubscher-Bruder V, Tsatsanis A, Duce JA, Tétard D, Bourne S, Maina M, Pienaar IS. Lewis FW, et al. Among authors: duce ja. Dalton Trans. 2022 Mar 1;51(9):3590-3603. doi: 10.1039/d1dt02604f. Dalton Trans. 2022. PMID: 35147617 Free PMC article.
Whole and fractionated human platelet lysate biomaterials-based biotherapy induces strong neuroprotection in experimental models of amyotrophic lateral sclerosis.
Gouel F, Timmerman K, Gosset P, Raoul C, Dutheil M, Jonneaux A, Garçon G, Moreau C, Danel-Brunaud V, Duce J, Burnouf T, Devedjian JC, Devos D. Gouel F, et al. Among authors: duce j. Biomaterials. 2022 Jan;280:121311. doi: 10.1016/j.biomaterials.2021.121311. Epub 2021 Dec 4. Biomaterials. 2022. PMID: 34952382 Free article.
70 results