Zhang R - Search Results

1

Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors.

Hanisak J, Seganish WM, McElroy WT, Tang H, Zhang R, Tsui HC, Fischmann T, Tulshian D, Tata J, Sondey C, Devito K, Fossetta J, Garlisi CG, Lundell D, Niu X. Hanisak J, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4250-5. doi: 10.1016/j.bmcl.2016.07.048. Epub 2016 Jul 22. Bioorg Med Chem Lett. 2016. PMID: 27476420

2

Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists.

Song F, Xu G, Gaul MD, Zhao B, Lu T, Zhang R, DesJarlais RL, DiLoreto K, Huebert N, Shook B, Rentzeperis D, Santulli R, Eckardt A, Demarest K. Song F, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1974-1980. doi: 10.1016/j.bmcl.2019.05.036. Epub 2019 May 18. Bioorg Med Chem Lett. 2019. PMID: 31138472

3

Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus.

Xu J, Lin S, Myers RW, Trujillo ME, Pachanski MJ, Malkani S, Chen HS, Chen Z, Campbell B, Eiermann GJ, Elowe N, Farrer BT, Feng W, Fu Q, Kats-Kagan R, Kavana M, McMasters DR, Mitra K, Tong X, Xu L, Zhang F, Zhang R, Addona GH, Berger JP, Zhang B, Parmee ER. Xu J, et al. Among authors: zhang r, zhang b, zhang f. Bioorg Med Chem Lett. 2017 May 1;27(9):2063-2068. doi: 10.1016/j.bmcl.2016.10.088. Epub 2016 Oct 31. Bioorg Med Chem Lett. 2017. PMID: 28284809

4

Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.

Xu J, Lin S, Myers RW, Addona G, Berger JP, Campbell B, Chen HS, Chen Z, Eiermann GJ, Elowe NH, Farrer BT, Feng W, Fu Q, Kats-Kagan R, Kavana M, Malkani S, McMasters DR, Mitra K, Pachanski MJ, Tong X, Trujillo ME, Xu L, Zhang B, Zhang F, Zhang R, Parmee ER. Xu J, et al. Among authors: zhang b, zhang r, zhang f. Bioorg Med Chem Lett. 2017 May 1;27(9):2069-2073. doi: 10.1016/j.bmcl.2016.10.085. Epub 2016 Oct 31. Bioorg Med Chem Lett. 2017. PMID: 28284804

5

Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists.

Zhang R, Wang A, DeAngelis A, Pelton P, Xu J, Zhu P, Zhou L, Demarest K, Murray WV, Kuo GH. Zhang R, et al. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3855-9. doi: 10.1016/j.bmcl.2007.05.007. Epub 2007 May 10. Bioorg Med Chem Lett. 2007. PMID: 17524639

6

N-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)picolinamide as a new inhibitor of mitochondrial complex III: Synthesis, biological evaluation and computational simulations.

Cheng H, Yang L, Liu HF, Zhang R, Chen C, Wu Y, Jiang W. Cheng H, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127302. doi: 10.1016/j.bmcl.2020.127302. Epub 2020 Jun 3. Bioorg Med Chem Lett. 2020. PMID: 32631522

7

Discovery of novel aminosaccharide-based sulfonamide derivatives as potential carbonic anhydrase II inhibitors.

Wang X, Feng YL, Zhao XY, An R, Cao C, Guo MB, Zhang R, Wang YX, Hou Z, Guo C. Wang X, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2021 Dec 1;53:128420. doi: 10.1016/j.bmcl.2021.128420. Epub 2021 Oct 30. Bioorg Med Chem Lett. 2021. PMID: 34728369

8

Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.

Zhang R, Deangelis A, Wang A, Sieber-McMaster E, Li X, Russell R, Pelton P, Xu J, Zhu P, Zhou L, Demarest K, Murray WV, Kuo GH. Zhang R, et al. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1101-4. doi: 10.1016/j.bmcl.2008.12.113. Epub 2009 Jan 8. Bioorg Med Chem Lett. 2009. PMID: 19168353

9

N-(3,5-Dichloro-4-(2,4,6-trichlorophenoxy)phenyl)benzenesulfonamide: A new dual-target inhibitor of mitochondrial complex II and complex III via structural simplification.

Cheng H, Liu HF, Yang L, Zhang R, Chen C, Wu Y, Jiang W. Cheng H, et al. Among authors: zhang r. Bioorg Med Chem. 2020 Mar 1;28(5):115299. doi: 10.1016/j.bmc.2019.115299. Epub 2019 Dec 30. Bioorg Med Chem. 2020. PMID: 31980361

10

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs.

Yang SM, Tang Y, Zhang R, Lu H, Kuo GH, Gaul MD, Li Y, Ho G, Conway JG, Liang Y, Lenhard JM, Demarest KT, Murray WV. Yang SM, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6773-6. doi: 10.1016/j.bmcl.2013.09.096. Epub 2013 Oct 9. Bioorg Med Chem Lett. 2013. PMID: 24153205

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