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Brain-penetrant LSD1 inhibitors can block memory consolidation.
Neelamegam R, Ricq EL, Malvaez M, Patnaik D, Norton S, Carlin SM, Hill IT, Wood MA, Haggarty SJ, Hooker JM. Neelamegam R, et al. Among authors: haggarty sj. ACS Chem Neurosci. 2012 Feb 15;3(2):120-128. doi: 10.1021/cn200104y. Epub 2011 Oct 18. ACS Chem Neurosci. 2012. PMID: 22754608 Free PMC article.
Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.
Fass DM, Reis SA, Ghosh B, Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Kuhnle CE, Tang W, Barker DD, Mazitschek R, Schreiber SL, Tsai LH, Haggarty SJ. Fass DM, et al. Among authors: haggarty sj. Neuropharmacology. 2013 Jan;64:81-96. doi: 10.1016/j.neuropharm.2012.06.043. Epub 2012 Jul 4. Neuropharmacology. 2013. PMID: 22771460 Free PMC article.
Epigenetic mechanisms in mood disorders: targeting neuroplasticity.
Fass DM, Schroeder FA, Perlis RH, Haggarty SJ. Fass DM, et al. Among authors: haggarty sj. Neuroscience. 2014 Apr 4;264:112-30. doi: 10.1016/j.neuroscience.2013.01.041. Epub 2013 Jan 30. Neuroscience. 2014. PMID: 23376737 Free PMC article. Review.
Class I HDAC imaging using [ (3)H]CI-994 autoradiography.
Wang Y, Zhang YL, Hennig K, Gale JP, Hong Y, Cha A, Riley M, Wagner F, Haggarty SJ, Holson E, Hooker J. Wang Y, et al. Among authors: haggarty sj. Epigenetics. 2013 Jul;8(7):756-64. doi: 10.4161/epi.25202. Epub 2013 Jun 11. Epigenetics. 2013. PMID: 23803584 Free PMC article.
A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests.
Schroeder FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM, Gale J, Zhao WN, Reis S, Barker DD, Berry-Scott E, Kim SW, Clore EL, Hooker JM, Holson EB, Haggarty SJ, Petryshen TL. Schroeder FA, et al. Among authors: haggarty sj. PLoS One. 2013 Aug 14;8(8):e71323. doi: 10.1371/journal.pone.0071323. eCollection 2013. PLoS One. 2013. PMID: 23967191 Free PMC article.
167 results