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RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.
Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J. Ito Y, et al. Among authors: li y. Science. 2016 Aug 5;353(6299):603-8. doi: 10.1126/science.aaf6803. Science. 2016. PMID: 27493188 Free PMC article.
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.
Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ, Yankner BA, Yuan J. Xu D, et al. Among authors: li y, li w. Cell. 2018 Sep 6;174(6):1477-1491.e19. doi: 10.1016/j.cell.2018.07.041. Epub 2018 Aug 23. Cell. 2018. PMID: 30146158 Free PMC article.
TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL.
Najafov A, Mookhtiar AK, Luu HS, Ordureau A, Pan H, Amin PP, Li Y, Lu Q, Yuan J. Najafov A, et al. Among authors: li y. Mol Cell. 2019 Aug 8;75(3):457-468.e4. doi: 10.1016/j.molcel.2019.05.022. Epub 2019 Jun 20. Mol Cell. 2019. PMID: 31230815 Free article.
Control of life-or-death decisions by RIP1 kinase.
Christofferson DE, Li Y, Yuan J. Christofferson DE, et al. Among authors: li y. Annu Rev Physiol. 2014;76:129-50. doi: 10.1146/annurev-physiol-021113-170259. Epub 2013 Sep 20. Annu Rev Physiol. 2014. PMID: 24079414 Review.
Small molecule probes for cellular death machines.
Li Y, Qian L, Yuan J. Li Y, et al. Curr Opin Chem Biol. 2017 Aug;39:74-82. doi: 10.1016/j.cbpa.2017.05.007. Epub 2017 Jun 16. Curr Opin Chem Biol. 2017. PMID: 28628894 Free PMC article. Review.
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