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RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.
Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J. Ito Y, et al. Among authors: yuan j. Science. 2016 Aug 5;353(6299):603-8. doi: 10.1126/science.aaf6803. Science. 2016. PMID: 27493188 Free PMC article.
Identification of RIP1 kinase as a specific cellular target of necrostatins.
Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Degterev A, et al. Among authors: yuan c, yuan j. Nat Chem Biol. 2008 May;4(5):313-21. doi: 10.1038/nchembio.83. Nat Chem Biol. 2008. PMID: 18408713 Free PMC article.
Parcs is a dual regulator of cell proliferation and apaf-1 function.
Sanchez-Olea R, Ortiz S, Barreto O, Yang Q, Xu CJ, Zhu H, Yuan J. Sanchez-Olea R, et al. Among authors: yuan j. J Biol Chem. 2008 Sep 5;283(36):24400-5. doi: 10.1074/jbc.M804664200. Epub 2008 Jun 18. J Biol Chem. 2008. PMID: 18562310 Free PMC article.
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