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Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases.
Heidari M, Gerami SH, Bassett B, Graham RM, Chua AC, Aryal R, House MJ, Collingwood JF, Bettencourt C, Houlden H, Ryten M; UK Brain Expression Consortium (UKBEC); Olynyk JK, Trinder D, Johnstone DM, Milward EA. Heidari M, et al. Among authors: johnstone dm. Rare Dis. 2016 Jun 22;4(1):e1198458. doi: 10.1080/21675511.2016.1198458. eCollection 2016. Rare Dis. 2016. PMID: 27500074 Free PMC article.
Hepatic iron loading in mice increases cholesterol biosynthesis.
Graham RM, Chua AC, Carter KW, Delima RD, Johnstone D, Herbison CE, Firth MJ, O'Leary R, Milward EA, Olynyk JK, Trinder D. Graham RM, et al. Hepatology. 2010 Aug;52(2):462-71. doi: 10.1002/hep.23712. Hepatology. 2010. PMID: 20683946
Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation.
Acikyol B, Graham RM, Trinder D, House MJ, Olynyk JK, Scott RJ, Milward EA, Johnstone DM. Acikyol B, et al. Among authors: johnstone dm. Neuroscience. 2013 Apr 3;235:119-28. doi: 10.1016/j.neuroscience.2013.01.014. Epub 2013 Jan 16. Neuroscience. 2013. PMID: 23333676
66 results