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Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases.
Heidari M, Gerami SH, Bassett B, Graham RM, Chua AC, Aryal R, House MJ, Collingwood JF, Bettencourt C, Houlden H, Ryten M; UK Brain Expression Consortium (UKBEC); Olynyk JK, Trinder D, Johnstone DM, Milward EA. Heidari M, et al. Among authors: milward ea. Rare Dis. 2016 Jun 22;4(1):e1198458. doi: 10.1080/21675511.2016.1198458. eCollection 2016. Rare Dis. 2016. PMID: 27500074 Free PMC article.
Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features.
Heidari M, Johnstone DM, Bassett B, Graham RM, Chua AC, House MJ, Collingwood JF, Bettencourt C, Houlden H, Ryten M, Olynyk JK, Trinder D, Milward EA. Heidari M, et al. Among authors: milward ea. Mol Psychiatry. 2016 Nov;21(11):1599-1607. doi: 10.1038/mp.2015.192. Epub 2016 Jan 5. Mol Psychiatry. 2016. PMID: 26728570 Free PMC article.
Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation.
Acikyol B, Graham RM, Trinder D, House MJ, Olynyk JK, Scott RJ, Milward EA, Johnstone DM. Acikyol B, et al. Among authors: milward ea. Neuroscience. 2013 Apr 3;235:119-28. doi: 10.1016/j.neuroscience.2013.01.014. Epub 2013 Jan 16. Neuroscience. 2013. PMID: 23333676
Gene co-expression networks shed light into diseases of brain iron accumulation.
Bettencourt C, Forabosco P, Wiethoff S, Heidari M, Johnstone DM, Botía JA, Collingwood JF, Hardy J; UK Brain Expression Consortium (UKBEC); Milward EA, Ryten M, Houlden H. Bettencourt C, et al. Among authors: milward ea. Neurobiol Dis. 2016 Mar;87:59-68. doi: 10.1016/j.nbd.2015.12.004. Epub 2015 Dec 18. Neurobiol Dis. 2016. PMID: 26707700 Free PMC article.
Clinical perspectives on hereditary hemochromatosis.
Ayonrinde OT, Milward EA, Chua AC, Trinder D, Olynyk JK. Ayonrinde OT, et al. Among authors: milward ea. Crit Rev Clin Lab Sci. 2008;45(5):451-84. doi: 10.1080/10408360802335716. Crit Rev Clin Lab Sci. 2008. PMID: 18712630 Review.
54 results